Brainsight TMS Navigation

Brainsight TMS Navigation is the world's leading neuronavigation system, currently in use in over 500 of the top neuroscience laboratories worldwide. Essential in improving the accuracy, reliability, and repeatability of non-invasive brain stimulation experiments, the Brainsight TMS Navigation system allows a user to position their TMS coil over a specified target location based upon the individual subject's MRI image, an MRI-generated 3D curvilinear reconstruction of the brain, or an MNI average head model brain. Brainsight TMS Navigation's features and functionality make the system ideal for fast, easy, and reliable target selection and coil positioning in all single-pulse TMS, paired-pulse TMS, repetitive TMS, and quadripulse stimulation (QPS) studies.

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Brainsight TMS Navigation

Brainsight TMS Navigation

What is Brainsight TMS Navigation?

The Brainsight TMS Navigation system is the world's leading neuronavigation device for researchers working with transcranial magnetic stimulation techniques. The navigation system is used by hundreds of leading neuroscientists worldwide, and the system's ability to offer researchers accurate, reliably and repeatable placement of a TMS coil has played a crucial role in supporting thousands of TMS publications in the 20 years since its creation.

The system's powerful - but simple-to-use - software offers users the ability to quickly design and set up a complete, neuronavigation TMS session within a matter of minutes, and provides researchers with fully customisable options to select registration landmarks, co-registration to standardised coordinate spaces, and even to configure multiple overlays for a truly deep and flexible experience.

Intuitive Workflows Demonstrated in Brainsight TMS Navigation

Targets for stimulation can be identified by manually selecting and highlighting the desired structure or location or by combining MRI images with areas of activity highlighted with fMRI, EEG or NIRS. Brainsight neuronavigation provides feedback on coil position and coil orientation (trajectory: pitch, tilt, and yaw) with respect to these predefined targets, critical in accurately repositioning the coil across multiple sessions.

Brainsight neuronavigation can also digitise the position of EEG electrodes for use in subsequent analyses. Brainsight can load sequence files, such as those used by BESA, to digitise electrodes in a particular order and digitise head shape to enable the co-registration of EEG electrode and MRI coordinate spaces.

Flexible Targeting in Brainsight TMS Navigation

It is also becoming increasingly popular to use simulations alongside software such as SimNIBS or ROAST to estimate current flow and electric field to identify sites that are most affected by tES montages. Brainsight can be used to digitise the position of tES electrodes that can then be used in electric field and current flow simulations.

Is the Brainsight TMS Navigation system right for me?

Neuronavigation systems are essential for researchers using non-invasive brain stimulation techniques where delivering stimulation accurately to a specific position on the subject's head is crucial to experimental success.

Brainsight TMS Navigation allows a researcher to track the position of their TMS coil in 3D space in real-time - the position of the coil is then tracked relative to an anatomical area of interest selected in the software. Brainsight not only tracks the position of the coil but also the orientation of the coil handle relative to the hotspot where the magnetic field is greatest.

Targeting Demonstrated in the Brainsight TMS Navigation Software

By employing neuronavigation technologies, researchers can reliably improve the accuracy and repeatability of their experiment as they are able to quickly and efficiently return to their chosen site of stimulation.

Brainsight-SimNIBS Integration & Feature Highlights: 

In this video, we explore the latest additions to Brainsight TMS Navigation, including the ability for operators to visualise current flow modelling calculations, performed by SimNIBS (Simulation of non-invasive brain stimulation), in the Brainsight GUI. The webinar will examine how a user can perform, interpret, and understand these calculations, as well as dedicate time to examine other new features that have been introduced into Brainsight over the past 12 months.

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Universal Compatibility in Brainsight TMS NavigationThanks to custom made TMS coil tracker fixation tools, Brainsight Neuronavigation can be used with all transcranial magnetic stimulation systems from any manufacturer and, more recently, transcranial focused ultrasound transducers. Quick calibration is made possible with adapters designed specifically for each coil or transducer.

Additionally, Brainsight accepts a huge variety of image formats: as well as the more commonly used DICOM, MINC and Analyze, MRI & fMRI images can also be loaded in the formats of PAR/REC, NIfTI, Siemens. Ima, and BrainVoyager.


Intuitive Workflows in Brainsight TMS Navigation

The step-by-step flow of building/creating a project within the Brainsight TMS Navigation system allows a user to set up and execute a TMS session in just a matter of minutes.

The Brainsight software includes dedicated pages for selecting registration landmarks, configuring multiple overlays and co-registration to standardised coordinate spaces. 


Flexible Targeting of Coordinates in Brainsight TMS Neuronavigation

Select targets based on anatomy, standardised coordinate spaces (MNI or Talairach), overlays (CT, EEG, fMRI, MEP, NIRS, PET etc); and recorded coil locations and trajectories from previous sessions.


Built-in EMG for MEP with the Brainsight TMS Neuronavigation System

The Brainsight TMS Neuronavigation system offers an optional computer cart featuring a built-in, two-channel EMG device that allows a researcher to automatically record MEP responses during a TMS experiment. These EMG responses can be used to generate smooth cartographic motor maps which can be viewed on the curvilinear reconstruction much like a functional overlay.


Automatic Curvilinear Reconstructions in BrainsightBrainsight's new automatic curvilinear reconstruction tools allow a researcher to reconstruct the whole brain or one hemisphere by inputting their desired stop depth and step size.

For other structures, the region paint tool can be used to delineate structures (e.g. cerebellum), which is then used to generate the curvilinear.


Brainsight TMS Navigation Region Painting ToolsNew features allow a user to paint a region for use in the Brainsight 3D reconstruction module, or to highlight their chosen brain structure. Painted regions may be exported to NIfTI files for use with other software.

Automatic Skin and Surface Reconstruction from ROI

Automatic Skin and Surfaces from ROIImproved tools make skin reconstruction easier than ever before. Brainsight also has the ability to build 3D surfaces using the results from the region of interest (ROI) tool, allowing the user to display anything they want.


Built-in voice recognition tools, and compatibility with Apple Remote or a TTL footswitch mean that a single user can execute the entire TMS session.


Brainsight Data is fully exportable in multiple formats for offline analysis of results. Additionally, multiple licenses on a single serial number allows for the remote working of Brainsight projects, pre and post stimulation.


Brainsight-SIMNIBS IntegrationRogue Research and Prof. Axel Thielscher (DRCMR) have collaborated to bring us a SimNIBS integrated version of Brainsight, currently available on beta release.

Results of SIMulated Non Invasive Brain Stimulation on an intended target can now be imported into Brainsight to generate E-Field measurements and plot them directly on the cortex. This new, novel feature can also be performed retrospectively, for those users who wish to view the e-field under an already stimulated area.

Tracking method

Optical (infrared) position sensor

Tracking tools

Subject tracker
Coil tracker(s)
Coil calibration block
Pointer tool

Supported file formats

DICOM, Analyse, NifTI, PAR/REC, MINC, BrainVoyager

MNI & Talairach coregistration

Using: MINC xdm files, SPM matrix, manual registration tool

Automatic 3D reconstructions

Full brain curvilinear
Skin, from anatomical MRI
Region of interest

Coil compatibility


MEP module (optional)

2 channels
Active ground shield

  1. Both dorsal and ventral attention network nodes are implicated in exogenously driven visuospatial anticipation. Merle-Marie Ahrens, Domenica VenieroaIng, Marie Freund, Monika Harvey, & GregorThut. Cortex. August 2019
  2. Egocentric processing in the roll plane and dorsal parietal cortex: A TMS-ERP study of the subjective visual vertical. Lina Willacker, James Dowsett, Marianne Dieterich, & Paul C.J.Taylor. Neuropsychologia. April 2019
  3. NeuroMeasure: A Software Package for Quantification of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation. Michael B. Gerber, Alasdair C. McLean, Samuel J. Stephen, Alex G. Chalco, Usman M. Arshad, Gary W. Thickbroom, Josh Silverstein, K. Zoe Tsagaris,2 Amy Kuceyeski, Kathleen Friel, Taiza E. G. Santos, and Dylan J. Edwards. Frontiers in Neuroinformatics. April 2019
  4. The temporal involvement of the left supramarginal gyrus in planning functional grasps: A neuronavigated TMS study. Weronika Potok, Adam Maskiewicz, Gregory Króliczak, & Mattia Marangon. Cortex. February 2019
  5. Optimized preoperative motor cortex mapping in brain tumors using advanced processing of transcranial magnetic stimulation data. Laura Seynaeve, Tom Haeck, Markus Gramer, Frederik Maes, Steven De Vleeschouwer, & Wim Van Paesschen
    . NeuroImage: Clinical. 2019
  6. Reproducibility and sources of interindividual variability in the responsiveness to prefrontal continuous theta burst stimulation (cTBS). Cassandra J. Lowe & Peter A. Hall. Neuroscience Letters. November 2018
  7. Neuromodulation of reinforced skill learning reveals the causal function of prefrontal cortex. Eran Dayan, Jasmine Herszage, Rony Laor‐Maayany, Haggai Sharon, & Nitzan Censor. Human Brain Mapping. July 2018
  8. Evidence for a subcortical contribution to intracortical facilitation. Patrick Wiegel, Niclas Niemann, John C. Rothwell, & Christian Leukel. European Journal of Neuroscience. May 2018
  9. Offline coil position denoising enhances detection of TMS effects. Leonardo Claudino, Sara J Hussain, Ethan R Buch, & Leonardo G Cohen. bioRxiv. January 2018
  10. Evidence of a Causal Role for mid-Ventrolateral Prefrontal Cortex Based Functional Networks in Retrieving High-Fidelity Memory. Peter E. Wais, Olivia Montgomery, Craig E. L. Stark & Adam Gazzaley. Scientific Reports. 2018
  11. Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study. Zarinah K. Agnew, Michael J. Banissy, Carolyn McGettigan, Vincent Walsh, and Sophie K. Scott. Frontiers in Human Neuroscience. 2018
  12. Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior. Mario Bogdanov, Jan E. Timmermann, Jan Gläscher, Friedhelm C. Hummel & Lars Schwabe. Scientific Reports. 2018
  13. Non-predictive online spatial coding in the posterior parietal cortex when aiming ahead for catching. Sinéad A. Reid & Joost C. Dessing. Scientific Reports. 2018
  14. TMS SMART – Scalp Mapping of Annoyance Ratings and Twitches caused by Transcranial
    Magnetic Stimulation
    . Lotte Meteyard & Nicholas Holmes. bioRxiv. 2017
  15. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Dominik Pizem, Lubomira Novakova, Martin Gajdos & Irena Rektorova. Journal of Neural Transmission. 2022
  16. Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements. Kevin A. Caulfield, Holly H. Fleischmann, Claire E. Cox, Julia P. Wolf, Mark S. George, Lisa M. McTeague. Brain Stimulation. August 2022

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Grant Applications, Industrial Projects, Workshops

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