Brainsight TMS Navigation

The Brainsight TMS Navigation system is a revolutionary product that has been used in over 500 world-leading neuroscience laboratories worldwide for over 20 years. The neuronavigation system enables a TMS coil to be positioned over a specified target location based upon an individual’s MRI image, MRI generated 3D curvilinear reconstruction of the brain, or MNI average head model brain. Brainsight’s features are ideal for target selection and coil positioning in single pulse TMS, paired pulse TMS, repetitive TMS, and quadri pulse stimulation (QPS) studies.

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Brainsight TMS Navigation

The Brainsight TMS Navigation system is the leading neuronavigation system for researchers working with transcranial magnetic stimulation and is used by hundreds of neuroscientists worldwide. Its powerful but easy-to-use software provides users with the ability to quickly set up a full, neuronavigated TMS session within a matter of minutes, with fully-customisable options to select registration landmarks, co-registration to standardised coordinate spaces, and to configure multiple overlays.

Targets for stimulation can be identified by manually selecting and highlighting the desired structure or location or by combining MRI images with areas of activity highlighted with fMRI, EEG or NIRS. Brainsight provides feedback on coil position and coil orientation (trajectory: pitch, tilt, and yaw) with respect to these predefined targets, critical in accurately repositioning the coil across multiple sessions.

Brainsight can also digitise the position of EEG electrodes for use in subsequent analyses. Brainsight can load sequences files, such as those used by BESA, to digitise electrodes in a particular order and digitise head shape to enable the co-registration of EEG electrode and MRI coordinate spaces.

It is also becoming increasingly popular to use simulations alongside software such as SimNIBS or ROAST to estimate current flow and electric field to identify sites that are most affected by tES montages. Brainsight can be used to digitise the position of tES electrodes that can then be used in electric field and current flow simulations.

Brainsight TMS navigation is Class I Medical Device according to the Medical Device Directive 93/42/ECC within the EU. Outside the EU Brainsight TMS is intended for Research purposes only.

UNIVERSAL COMPATIBILITY

Universal Compatibility in Brainsight TMS NavigationThanks to custom made TMS coil tracker fixation tools, Brainsight Neuronavigation can be used with all transcranial magnetic stimulation systems from any manufacturer and, more recently, transcranial focused ultrasound transducers. Quick calibration is made possible with adapters designed specifically for each coil or transducer.

Additionally, Brainsight accepts a huge variety of image formats: as well as the more commonly used DICOM, MINC and Analyze, MRI & fMRI images can also be loaded in the formats of PAR/REC, NIfTI, Siemens. Ima, and BrainVoyager.

INTUITIVE WORKFLOW

Intuitive Workflows in Brainsight TMS Navigation

The step-by-step flow of building/creating a project within the Brainsight TMS Navigation system allows a user to set up and execute a TMS session in just a matter of minutes.

The Brainsight software includes dedicated pages for selecting registration landmarks, configuring multiple overlays and co-registration to standardised coordinate spaces. 

FLEXIBLE TARGETING

Flexible Targeting of Coordinates in Brainsight TMS Neuronavigation

Select targets based on anatomy, standardised coordinate spaces (MNI or Talairach), overlays (CT, EEG, fMRI, MEP, NIRS, PET etc); and recorded coil locations and trajectories from previous sessions.

BUILT-IN EMG FOR MEP

Built-in EMG for MEP

The Brainsight TMS Neuronavigation system offers an optional computer cart featuring a built-in, two-channel EMG device that allows a researcher to automatically record MEP responses during a TMS experiment. These EMG responses can be used to generate smooth cartographic motor maps which can be viewed on the curvilinear reconstruction much like a functional overlay.

OFFLINE WORKING

Brainsight Data is fully exportable in multiple formats for offline analysis of results. Additionally, multiple licenses on a single serial number allows for the remote working of Brainsight projects, pre and post stimulation.

BRAINSIGHT/SIMNIBS COLLABORATION

Brainsight-SIMNIBS IntegrationRogue Research and Prof. Axel Thielscher (DRCMR) have collaborated to bring us a SimNIBS integrated version of Brainsight, currently available on beta release.

Results of SIMulated Non Invasive Brain Stimulation on an intended target can now be imported into Brainsight to generate E-Field measurements and plot them directly on the cortex. This new, novel feature can also be performed retrospectively, for those users who wish to view the e-field under an already stimulated area.

Tracking method

Optical (infrared) position sensor

Tracking tools

Subject tracker
Coil tracker(s)
Coil calibration block
Pointer tool

Supported file formats

DICOM, Analyse, NifTI, PAR/REC, MINC, BrainVoyager

MNI & Talairach coregistration

Using: MINC xdm files, SPM matrix, manual registration tool

Automatic 3D reconstructions

Full brain curvilinear
Skin, from anatomical MRI
Region of interest
Overlays

Coil compatibility

Universal

MEP module (optional)

2 channels
Active ground shield

  1. Both dorsal and ventral attention network nodes are implicated in exogenously driven visuospatial anticipation. Merle-Marie Ahrens, Domenica VenieroaIng, Marie Freund, Monika Harvey, & GregorThut. Cortex. August 2019
  2. Egocentric processing in the roll plane and dorsal parietal cortex: A TMS-ERP study of the subjective visual vertical. Lina Willacker, James Dowsett, Marianne Dieterich, & Paul C.J.Taylor. Neuropsychologia. April 2019
  3. NeuroMeasure: A Software Package for Quantification of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation. Michael B. Gerber, Alasdair C. McLean, Samuel J. Stephen, Alex G. Chalco, Usman M. Arshad, Gary W. Thickbroom, Josh Silverstein, K. Zoe Tsagaris,2 Amy Kuceyeski, Kathleen Friel, Taiza E. G. Santos, and Dylan J. Edwards. Frontiers in Neuroinformatics. April 2019
  4. The temporal involvement of the left supramarginal gyrus in planning functional grasps: A neuronavigated TMS study. Weronika Potok, Adam Maskiewicz, Gregory Króliczak, & Mattia Marangon. Cortex. February 2019
  5. Optimized preoperative motor cortex mapping in brain tumors using advanced processing of transcranial magnetic stimulation data. Laura Seynaeve, Tom Haeck, Markus Gramer, Frederik Maes, Steven De Vleeschouwer, & Wim Van Paesschen
    . NeuroImage: Clinical. 2019
  6. Reproducibility and sources of interindividual variability in the responsiveness to prefrontal continuous theta burst stimulation (cTBS). Cassandra J. Lowe & Peter A. Hall. Neuroscience Letters. November 2018
  7. Neuromodulation of reinforced skill learning reveals the causal function of prefrontal cortex. Eran Dayan, Jasmine Herszage, Rony Laor‐Maayany, Haggai Sharon, & Nitzan Censor. Human Brain Mapping. July 2018
  8. Evidence for a subcortical contribution to intracortical facilitation. Patrick Wiegel, Niclas Niemann, John C. Rothwell, & Christian Leukel. European Journal of Neuroscience. May 2018
  9. Offline coil position denoising enhances detection of TMS effects. Leonardo Claudino, Sara J Hussain, Ethan R Buch, & Leonardo G Cohen. bioRxiv. January 2018
  10. Evidence of a Causal Role for mid-Ventrolateral Prefrontal Cortex Based Functional Networks in Retrieving High-Fidelity Memory. Peter E. Wais, Olivia Montgomery, Craig E. L. Stark & Adam Gazzaley. Scientific Reports. 2018
  11. Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study. Zarinah K. Agnew, Michael J. Banissy, Carolyn McGettigan, Vincent Walsh, and Sophie K. Scott. Frontiers in Human Neuroscience. 2018
  12. Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior. Mario Bogdanov, Jan E. Timmermann, Jan Gläscher, Friedhelm C. Hummel & Lars Schwabe. Scientific Reports. 2018
  13. Non-predictive online spatial coding in the posterior parietal cortex when aiming ahead for catching. Sinéad A. Reid & Joost C. Dessing. Scientific Reports. 2018
  14. TMS SMART – Scalp Mapping of Annoyance Ratings and Twitches caused by Transcranial
    Magnetic Stimulation
    . Lotte Meteyard & Nicholas Holmes. bioRxiv. 2017

Associated Techniques

To find out more about the techniques that are applicable to this product, follow the links below.

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Training
Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Collaboration
Grant Applications, Industrial Projects, Workshops

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