Brainsight TMS Navigation is the world's leading neuronavigation system, currently in use in over 500 of the top neuroscience laboratories worldwide. Essential in improving the accuracy, reliability, and repeatability of non-invasive brain stimulation experiments, the Brainsight TMS Navigation system allows a user to position their TMS coil over a specified target location based upon the individual subject's MRI image, an MRI-generated 3D curvilinear reconstruction of the brain, or an MNI average head model brain. Brainsight TMS Navigation's features and functionality make the system ideal for fast, easy, and reliable target selection and coil positioning in all single-pulse TMS, paired-pulse TMS, repetitive TMS, and quadripulse stimulation (QPS) studies.
Brainsight TMS Navigation
What is Brainsight TMS Navigation?
The Brainsight TMS Navigation system is the world's leading neuronavigation device for researchers working with transcranial magnetic stimulation techniques. The navigation system is used by hundreds of leading neuroscientists worldwide, and the system's ability to offer researchers accurate, reliably and repeatable placement of a TMS coil has played a crucial role in supporting thousands of TMS publications in the 20 years since its creation.
The system's powerful - but simple-to-use - software offers users the ability to quickly design and set up a complete, neuronavigation TMS session within a matter of minutes, and provides researchers with fully customisable options to select registration landmarks, co-registration to standardised coordinate spaces, and even to configure multiple overlays for a truly deep and flexible experience.
Targets for stimulation can be identified by manually selecting and highlighting the desired structure or location or by combining MRI images with areas of activity highlighted with fMRI, EEG or NIRS. Brainsight neuronavigation provides feedback on coil position and coil orientation (trajectory: pitch, tilt, and yaw) with respect to these predefined targets, critical in accurately repositioning the coil across multiple sessions.
Brainsight neuronavigation can also digitise the position of EEG electrodes for use in subsequent analyses. Brainsight can load sequence files, such as those used by BESA, to digitise electrodes in a particular order and digitise head shape to enable the co-registration of EEG electrode and MRI coordinate spaces.
It is also becoming increasingly popular to use simulations alongside software such as SimNIBS or ROAST to estimate current flow and electric field to identify sites that are most affected by tES montages. Brainsight can be used to digitise the position of tES electrodes that can then be used in electric field and current flow simulations.
Is the Brainsight TMS Navigation system right for me?
Neuronavigation systems are essential for researchers using non-invasive brain stimulation techniques where delivering stimulation accurately to a specific position on the subject's head is crucial to experimental success.
Brainsight TMS Navigation allows a researcher to track the position of their TMS coil in 3D space in real-time - the position of the coil is then tracked relative to an anatomical area of interest selected in the software. Brainsight not only tracks the position of the coil but also the orientation of the coil handle relative to the hotspot where the magnetic field is greatest.
By employing neuronavigation technologies, researchers can reliably improve the accuracy and repeatability of their experiment as they are able to quickly and efficiently return to their chosen site of stimulation.
Brainsight-SimNIBS Integration & Feature Highlights:
In this video, we explore the latest additions to Brainsight TMS Navigation, including the ability for operators to visualise current flow modelling calculations, performed by SimNIBS (Simulation of non-invasive brain stimulation), in the Brainsight GUI. The webinar will examine how a user can perform, interpret, and understand these calculations, as well as dedicate time to examine other new features that have been introduced into Brainsight over the past 12 months.
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UNIVERSAL COMPATIBILITY
Thanks to custom made TMS coil tracker fixation tools, Brainsight Neuronavigation can be used with all transcranial magnetic stimulation systems from any manufacturer and, more recently, transcranial focused ultrasound transducers. Quick calibration is made possible with adapters designed specifically for each coil or transducer.
Additionally, Brainsight accepts a huge variety of image formats: as well as the more commonly used DICOM, MINC and Analyze, MRI & fMRI images can also be loaded in the formats of PAR/REC, NIfTI, Siemens. Ima, and BrainVoyager.
INTUITIVE WORKFLOW
The step-by-step flow of building/creating a project within the Brainsight TMS Navigation system allows a user to set up and execute a TMS session in just a matter of minutes.
The Brainsight software includes dedicated pages for selecting registration landmarks, configuring multiple overlays and co-registration to standardised coordinate spaces.
FLEXIBLE TARGETING
BUILT-IN EMG FOR MEP
The Brainsight TMS Neuronavigation system offers an optional computer cart featuring a built-in, two-channel EMG device that allows a researcher to automatically record MEP responses during a TMS experiment. These EMG responses can be used to generate smooth cartographic motor maps which can be viewed on the curvilinear reconstruction much like a functional overlay.
AUTOMATIC CURVILINEAR RECONSTRUCTION
Brainsight's new automatic curvilinear reconstruction tools allow a researcher to reconstruct the whole brain or one hemisphere by inputting their desired stop depth and step size.
For other structures, the region paint tool can be used to delineate structures (e.g. cerebellum), which is then used to generate the curvilinear.
REGION PAINTING TOOLS
New features allow a user to paint a region for use in the Brainsight 3D reconstruction module, or to highlight their chosen brain structure. Painted regions may be exported to NIfTI files for use with other software.
Automatic Skin and Surface Reconstruction from ROI
Improved tools make skin reconstruction easier than ever before. Brainsight also has the ability to build 3D surfaces using the results from the region of interest (ROI) tool, allowing the user to display anything they want.
SINGLE USER OPERATION
Built-in voice recognition tools, and compatibility with Apple Remote or a TTL footswitch mean that a single user can execute the entire TMS session.
OFFLINE WORKING
Brainsight Data is fully exportable in multiple formats for offline analysis of results. Additionally, multiple licenses on a single serial number allows for the remote working of Brainsight projects, pre and post stimulation.
BRAINSIGHT/SIMNIBS COLLABORATION
Rogue Research and Prof. Axel Thielscher (DRCMR) have collaborated to bring us a SimNIBS integrated version of Brainsight, currently available on beta release.
Results of SIMulated Non Invasive Brain Stimulation on an intended target can now be imported into Brainsight to generate E-Field measurements and plot them directly on the cortex. This new, novel feature can also be performed retrospectively, for those users who wish to view the e-field under an already stimulated area.
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Tracking method |
Optical (infrared) position sensor |
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Tracking tools |
Subject tracker |
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Supported file formats |
DICOM, Analyse, NifTI, PAR/REC, MINC, BrainVoyager |
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MNI & Talairach coregistration |
Using: MINC xdm files, SPM matrix, manual registration tool |
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Automatic 3D reconstructions |
Full brain curvilinear |
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Coil compatibility |
Universal |
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MEP module (optional) |
2 channels |
- Chronometric interleaved TMS-fMRI shows state-dependent network effects underlying speech production. Vasileiadi, M., Schuler, A.-L., Woletz, M., Witz, V., Grosshagauer, S., Coetzee, J., & Tik, M. (2026). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 19(1).
- Distinct and complementary mechanisms of oscillatory and aperiodic alpha activity in visuospatial attention. Lu, R., Pollitt, E., & Woolgar, A. (2025). Imaging Neuroscience, 3, IMAG.a.1038.
- Optimizing the identification of long-interval intracortical inhibition from the dorsolateral prefrontal cortex. Takano, M., Wada, M., Nakajima, S., Taniguchi, K., Honda, S., Mimura, Y., Kitahata, R., Zomorrodi, R., Blumberger, D. M., Daskalakis, Z. J., Uchida, H., Mimura, M., & Noda, Y. (2025). Clinical Neurophysiology, 169, 102–113.
- Validation of an electroencephalography data assimilation-based computational approach for estimating cortical excitation-inhibition balance. Yokoyama, H., Noda, Y., Wada, M., Takano, M., & Kitajo, K. (2025). Communications Engineering, 4(1), 195.
- Neuroplasticity of the left dorsolateral prefrontal cortex in patients with treatment-resistant depression as indexed with paired associative stimulation: A TMS–EEG study. Kaneko, N., Wada, M., Nakajima, S., Takano, M., Taniguchi, K., Honda, S., Mimura, M., & Noda, Y. (2024). Cerebral Cortex, 34(2).
- Immediate effect of quadri-pulse stimulation on human brain microstructures and functions. Kimura, I., Hayashi, M. J., & Amano, K. (2024). Imaging Neuroscience, 2, imag–2–00264.
- Development of Artificial Intelligence for Determining Major Depressive Disorder Based on Resting-State EEG and Single-Pulse Transcranial Magnetic Stimulation-Evoked EEG Indices. Noda, Y., Sakaue, K., Wada, M., Takano, M., & Nakajima, S. (2024). Journal of Personalized Medicine, 14(1), 101.
- Decreased prefrontal glutamatergic function is associated with a reduced astrocyte-related gene expression in treatment-resistant depression. Wada, M., Nakajima, S., Honda, S., Takano, M., Taniguchi, K., Homma, S., Ueda, R., Tobari, Y., Mimura, Y., Fujii, S., Mimura, M., & Noda, Y. (2024). Translational Psychiatry, 14(1), 478.
- Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements. Caulfield, K. A., Fleischmann, H. H., Cox, C. E., Wolf, J. P., George, M. S., & McTeague, L. M. (2022). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 15(5), 1192–1205.
- Cortical excitability in a nonhuman primate model of TMS. Hanlon, C. A., Czoty, P. W., Smith, H. R., Epperly, P. M., & Galbo, L. K. (2021). Brain Stimulation, 14(1), 19–21.
- Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson’s disease. Brabenec, L., Klobusiakova, P., Barton, M., Mekyska, J., Galaz, Z., Zvoncak, V., Kiska, T., Mucha, J., Smekal, Z., Kostalova, M., & Rektorova, I. (2019). Parkinsonism & Related Disorders, 61, 187–192.
- Optimized preoperative motor cortex mapping in brain tumors using advanced processing of transcranial magnetic stimulation data. Seynaeve, L., Haeck, T., Gramer, M., Maes, F., De Vleeschouwer, S., & Van Paesschen, W. (2019). NeuroImage: Clinical, 21, 101657.
- Non-predictive online spatial coding in the posterior parietal cortex when aiming ahead for catching. Reid, S. A., & Dessing, J. C. (2018). Scientific Reports, 8(1), 7756.
- Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study. Agnew, Z. K., Banissy, M. J., McGettigan, C., Walsh, V., & Scott, S. K. (2018). Frontiers in Human Neuroscience, 12, 150.
- Neuromodulation of reinforced skill learning reveals the causal function of prefrontal cortex. Dayan, E., Herszage, J., Laor‐Maayany, R., Sharon, H., & Censor, N. (2018). Human Brain Mapping, 39(12), 4724–4732.
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
- DuoMAG MP
- DuoMAG MP-Dual
- DuoMAG MP-Quad
- DuoMAG XT
- Elevate TMS (cTMS)
- nurostym tES
- neuroConn DC-Stimulator PLUS
- Smarting PRO X
- Smarting PRO
- Gowerlabs LUMO fNIRS
- Axilum TMS-Robot
- Axilum TMS-Cobot
- neuroConn DC-Stimulator MC
- Brainsight TMS Chair
- NeuroFUS PRO
- MAG4Health 4He OPM-MEG System
- TruScan Research EEG
- NEURO PRAX DC-EEG
- TUS Package
- neuroConn LOOP-IT
- TMS-fNIRS Package
- BESA Research Software
Associated Techniques
To find out more about the techniques that are applicable to this product, follow the links below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops
