DuoMAG MP-Quad
What is Quadripulse TMS?
Quadripulse* transcranial magnetic stimulation (QPS) is a novel method of repetitive transcranial magnetic stimulation (rTMS) that can be used to either increase or decrease cortical excitability in a subject.
The Power of Four Monophasic Stimulators
The DuoMAG MP-Quad system comprises four powerful DuoMAG MP monophasic stimulators, bundled with an additional, intelligent 'CombiBox' unit to allow for communication between the individual stimulators.
As well as delivering quadripulse stimulation, each DuoMAG MP unit that makes up the MP-Quad system is capable of being used as its own, independent monophasic system or as up to two paired-pulse (ppTMS) systems for the ultimate flexibility in research applications.
Additionally, where research conditions require the functionality, the DuoMAG MP-Quad is capable of delivering stimulation through four separate coils at the same time for interhemispheric (quadrilateral) stimulation.
Complete Freedom of Control Over Stimulation Parameters
When controlled via the native DuoMAG software, the DuoMAG MP-Quad is capable of delivering single-pulse TMS, paired-pulse TMS, defined QPS protocols and controlling all four stimulators separately to accomplish up to four coil stimulation for the investigation of inter-hemispheric stimulation.
The DuoMAG software provides intuitive, easy-to-use controls for a researcher, enabling full control of all stimulation parameters.
Stimulator outputs can all be set individually, or can even be combined to deliver pulses at up to 134% of a single stimulator's output through one TMS coil. Additionally, the inter-stimulus intervals (ISI) are configurable to a resolution as low as 0.1ms. The MP-Quad can be configured to allow for slow repetitive monophasic stimulation at up to 8Hz, with stimulation at 100% output as high as 2Hz.
USB 2.0 and TTL connections on the reverse of each stimulator allow for external control of individual stimulators and a programmable capacitor recharge delay can be utilised in instances of concurrent TMS-EEG studies.
Universal DuoMAG Coil Compatibility
The DuoMAG MP-Quad is compatible with the full range of DuoMAG TMS coils, allowing the system to be used for any research application. All DuoMAG TMS coils feature built-in controls in the coil handle to remotely adjust stimulator intensity, as well as a button to trigger stimulation.
*Quadripulse stimulation is sometimes alternatively referred to as 'Quadropulse' TMS by researchers.
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FULLY PROGRAMMABLE PROTOCOLS
FULLY PROGRAMMABLE QPS
MODULAR DESIGN
UNIVERSAL COIL COMPATIBILITY
Stimulation mode |
Single Pulse |
Paired Pulse |
Quadripulse |
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Pulse shape |
Monophasic |
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Pulse width (rise/decay) |
100, 120µs / 1.0, 1.2ms |
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Max energy |
700J (at 100%) |
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Max repetition rate at 100% |
2.0Hz |
1.0Hz |
0.5Hz |
Max repetition rate at 50% |
5.6Hz |
2.8Hz |
1.4Hz |
Max repetition rate |
8.0Hz |
4.0Hz |
2.0Hz |
Inter stimulus interval (ISI) |
n/a |
≥1.0ms |
≥1.0ms |
Coil connections |
up to 4 |
up to 2 |
1 |
Synchronisation |
TTL in/out, via BNC |
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Communication |
USB or coil controls |
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Power supply |
4 x (100-240Vac 50/60Hz) |
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Dimensions |
4 x (49cm x 19cm x 38cm) |
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Weight |
60kg |
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Graphical user interface |
Optional |
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Trolley with coil holder |
Optional |
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- Region-dependent bidirectional plasticity in M1 following quadripulse transcranial magnetic stimulation in the inferior parietal cortex. Fuminari Kaneko, Eriko Shibata, Megumi Okawada, & Takashi Nagamine. Brain Stimulation. April 2020
- Plasticity induction in the pre-supplementary motor area (pre-SMA) and SMA-proper differentially affects visuomotor sequence learning. Takahiro Shimizua, Ritsuko Hanajima, Yuichiro Shirota, Ryosuke Tsutsumi, Nobuyuki Tanaka, Yasuo Terao, Masashi Hamada, & Yoshikazu Ugawa. Brain Stimulation. February 2020
- Quadripulse stimulation: A replication study with a newly developed stimulator. Ikko Kimura, Yoshikazu Ugawa, Masamichi J. Hayashi, Kaoru Amano.. Brain Stimulation. March 2022
- Quadripulse stimulation: A replication study with a newly developed stimulator. Ikko Kimura, Yoshikazu Ugawa, Masamichi J. Hayashi, Kaoru Amano. Brain Stimulation. May 2022
- Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics. Takamitsu Watanabe. eLife 10:e69079.. October 2021
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops