The DuoMAG XT is a powerful, flexible repetitive transcranial magnetic stimulator built for ease of use in both research and clinical scenarios.
DuoMAG XT
What is Repetitive Transcranial Magnetic Stimulation (rTMS)?
Repetitive transcranial magnetic stimulation (rTMS), delivered by the DuoMAG XT rTMS system, can be applied to increase or decrease the excitability of the corticospinal tract depending on the intensity of stimulation, coil orientation, and frequency.
DuoMAG XT, for rTMS Applications
Available in three different iterations and a multitude of different configurations, the DuoMAG XT is the flagship rTMS device available from Brainbox.
With a focus on user-friendliness, the system's proprietary software houses a powerful 5kHz EMG software for the recording and analysis of MEPs. Patient data and session history can be saved, exported and anonymised, and a purpose-built TMS protocol builder enables allows for the simple creation of rTMS trains and theta burst protocols for both research and clinical applications.
The range-topping DuoMAG XT100 is capable of delivering 100Hz stimulation at 40% stimulator output and theta burst at 67% stimulator output. DuoMAG XT35 and XT10 stimulators are capable of delivering rTMS at 35Hz and 10Hz respectively.
Brainbox understands the need for flexible solutions within the workspace, and so is proud to offer the DuoMAG XT in three different configurations. A desktop set-up can be requested for laboratories without the available space for a cart. For those who’d prefer a more portable solution, the DuoMAG TMS cart with coil arm allows the stimulator and optional touchscreen computer to be moved easily between sites. Finally, popular in clinical institutions is the counterbalanced, electromagnetically-operated coil arm, designed specifically to help keep the coil position stable during longer rTMS sessions.
All DuoMAG XT stimulators can be controlled externally via TTL, USB 2.0 or via ethernet connection for flexible research applications.
All DuoMAG systems also offer complete control over stimulator intensity and triggering via the built-in controls located on the coil handles (pictured below).
Clinical Applications of rTMS
Repetitive TMS has been used in a number of clinical applications and rigorous studies in the past several years. Research using rTMS protocols has suggested that rTMS can be effective in the treatment of a number of neurological and psychiatric diseases including:
- Depression
- Parkinson's Disease
- Epilepsy
- Movement Disorders
- Chronic pain and migraine
- Tinnitus
An overview of the clinical applications of rTMS can be found in this journal reference.
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CUSTOM PROTOCOL EDITOR
Intuitive software allows for the easy control of subject database, including fully anonymising data and exporting stimulation history. A dedicated screen for the calculation of resting motor threshold (RMT) and active motor threshold (AMT), with the ability to add/edit cursors to highlight amplitude/latency.
The DuoMAG XT's custom protocol editor enables the customisation of all stimulation parameters, including repetitive trains, stimulation frequency, burst frequency, and stimulation at a percentage of motor threshold.
AUTOMATIC MEP AMPLITUDE CALCULATION
Following the delivery of a TMS pulse in single pulse mode, the DuoMAG EMG software is configured to record and plot the highest and lowest peaks of the resulting motor evoked potential (MEP). Latency information can be added, together with manipulation of the cursors where necessary.
MEP data is stored and used for the calculation of stimulator intensity when delivering repetitive TMS (rTMS) protocols.
All MEP data and information can be exported in multiple formats for offline analysis.
ACTIVE MOTOR THRESHOLD CALCULATION
When calculating an active motor threshold (AMT), it is first necessary to record the participant's maximum voluntary isometric contraction (MVIC) before performing a contraction to a target percentage of this value.
A built-in feature of the DuoMAG software enables the researcher to calibrate both of these responses, and record active motor threshold values, while displaying a colour-coded target value for the participant.
EXTERNAL COMMUNICATIONS
MULTIMODAL APPLICATIONS
The DuoMAG XT rTMS system offers seamless integration through the whole family of Deymed products for true multimodal research studies. Deymed EEG, EMG/MEP systems can control intensity and triggering of TMS devices enabling the user to maintain focus and attention on the participant, rather than the hardware.
MULTIPLE CONFIGURATIONS
Three different repetitive stimulator options and two different cart options enable us to specify a system to any budget or requirement. Standalone systems can be used for desktop workspaces, a cart enables the system to be mounted on a trolley and be portable for use in different sites and an optional counterbalanced electromagnetically operated arm can be specified to ensure coil movement is eliminated in a session. This flexibility, coupled with a wide range of coil types makes the DuoMAG systems unrivalled in terms of their customisation.
CE-CERTIFICATION
The DuoMAG XT rTMS system is a CE-certified medical device for non-invasive brain stimulation in humans. It is limited to investigational and research use in the USA.
This system is also available as a research-only device, which has the same electrical safety testing as the medically-certified device, but without the clinical indications. This version is intended for academic neuroscience research only, in applicable countries and territories.
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XT-10 |
XT-35 |
XT-100 |
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Stimulation modes |
Single pulse and repetitive |
Single pulse, repetitive and burst |
Single pulse, repetitive and burst |
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Pulse shape |
Biphasic |
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Pulse width |
290µs |
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Max energy |
265J (optionally 320J) |
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Max repetition rate at 100% |
5Hz |
13Hz |
22Hz |
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Max repetition rate at 50% |
10Hz |
35Hz |
86Hz |
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Max repetition rate |
10Hz |
35Hz |
100Hz |
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Max frequency |
10Hz |
35Hz |
100Hz |
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Synchronisation |
TTL in/out, via BNC |
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Communication |
USB or coil controls |
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Power supply |
100-240Vac 50/60Hz |
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Dimensions |
49cm x 38cm x 16cm |
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Weight |
15kg |
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Graphical user interface |
Included |
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Trolley with coil holder |
Included |
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Electromagnetic coil arm |
Optional |
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EMG module |
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EMG channels |
2 or 4, bipolar |
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Notch filter |
50Hz and 60Hz (selectable) |
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Sampling rate |
3kHz |
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Peak-to-peak amplitude measurement |
Automatic |
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Latency measurement |
Manual |
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Motor threshold tools |
Resting (RMT) |
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GUI features |
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Patient detail entry |
Yes |
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Programmable trains |
Yes |
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Store/load protocols |
Yes |
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Store/load MEPs |
Yes |
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Change power within train |
Yes |
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Data export |
Yes |
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- Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Dominik Pizem, Lubomira Novakova, Martin Gajdos & Irena Rektorova. Journal of Neural Transmission. 25/01/2022
- Hebbian Activity-Dependent Plasticity in White Matter. Lazari, A., Salvan, P., Cottaar, M., Papp. D., Rushworth, M., and Johansen-Berg, H. Cell Reports. December 2021
- Prefrontal stimulation prior to motor sequence learning alters multivoxel patterns in the striatum and the hippocampus. Mareike A. Gann, Bradley R. King, Nina Dolfen, Menno P. Veldman, Marco Davare, Stephan P. Swinnen, Dante Mantini, Edwin M. Robertson & Geneviève Albouy. Scientific Reports. October 2021
- Functional Connectivity at Rest between the Human Medial Posterior Parietal Cortex and the Primary Motor Cortex Detected by Paired-Pulse Transcranial Magnetic Stimulation. Rossella Breveglieri, Sara Borgomaneri, Matteo Filippini, Marina De Vitis, Alessia Tessari, Patrizia Fattori. Brain Sciences. October 2021
- Development of an Advanced Sham Coil for Transcranial Magnetic Stimulation and Examination of Its Specifications. Mayuko Takano, Jiri Havlicek, Dan Phillips, Shinichiro Nakajima, Masaru Mimura, and Yoshihiro Noda. Journal of Personalized Medicine. October 2021
- Seizure risk with repetitive TMS: Survey results from over a half-million treatment sessions.. Joseph J. Taylor, Noam G. Newberger, Adam P. Stern, Angela Phillips, David Feifel, Rebecca, A. Betensky, Daniel Z. Press. Brain Stimulation. August 2021
- Impact of one HF-rTMS session over the DLPFC and motor cortex on acute hormone dynamics and emotional state in healthy adults: a sham-controlled pilot study. Blair T. Crewther, Wiktoria Kasprzycka, Christian J. Cook & Rafał Rola. Neurological Sciences. May 2021
- Prefrontal stimulation prior to motor sequence learning alters multivoxel patterns in the striatum and the hippocampus. Mareike Gann, Bradley King, Nina Dolfen, Menno Veldman, Marco Davare, Stephen Swinnen, Dante Mantini, Edwin Robertson & Genevieve Albouy. Neuroimage. May 2021
- Low-frequency rTMS to the parietal lobe increases eye-movement carryover and decreases hazard rating. P.J. Hills, G. Arabaci, J. Fagg, C. Thompson & R. Moseley. Neuropsychologia. May 2021
- Short-Term Immobilization Promotes a Rapid Loss of Motor Evoked Potentials and Strength That Is Not Rescued by rTMS Treatment. Christopher Gaffney, Amber Drinkwater, Shalmali Joshi, Brandon O’Hanlon, Abbie Robinson, Kayle-Anne Sands, Kate Slade, Jason Braithwaite and Helen Nuttall. Frontiers in Human Neuroscience. April 2021
- Natural oscillation frequencies in the two lateral prefrontal cortices induced by Transcranial Magnetic Stimulation. Antonino Vallesi, Alessandra Del Felice, Mariagrazi Capizzi, Alessandra Tafuro, Emanuela Formaggio, Patrizia Bisiacchi, Stefano Masiero, Ettore Ambrosini. Neuroimage. February 2021
- Motor resonance is modulated by an object’s weight distribution. Guy Rens, Jean-Jacques Orban de Xivry, Marco Davare, Vonne van Polanen. Neuropsychologia. 2021
- Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography. Yu Zhang, Wei Wu, Russell T. Toll, Sharon Naparstek, Adi Maron-Katz, Mallissa Watts, Joseph Gordon, Jisoo Jeong, Laura Astolfi, Emmanuel Shpigel, Parker Longwell, Kamron Sarhadi, Dawlat El-Said, Yuanqing Li, Crystal Cooper, Cherise Chin-Fatt, Martijn Arns. Nature Biomedical Engineering. October 2020
- Enhancing cognitive training effects in Alzheimer’s disease: rTMS as an add-on treatment. Bagattini Chiara, Zanni Mara, Barocco Federica, Caffarra Paolo, Brignani Debora, Miniussi Carlo, Defanti Carlo Alberto. Brain Stimulation. September 2020
- The role of the anterior intraparietal sulcus and the lateral occipital cortex in fingertip force scaling and weight perception during object lifting. Vonne van Polanen, Guy Rens, and Marco Davare. Journal of Neurophysiology. August 2020
- Sensorimotor expectations bias motor resonance during observation of object lifting: The causal role of pSTS. Guy Rens, Vonne van Polanen, Alessandro Botta, Mareike A. Gann, Jean-Jacques Orban de Xivry and Marco Davare. Journal of Neuroscience, JN-RM-2672-19. April 2020
- An electroencephalographic signature predicts antidepressant response in major depression. Wei Wu, Yu Zhang, […] Amit Etkin. Nature Biotechnology. February 2020
- Theta-burst transcranial magnetic stimulation induced cognitive task-related decrease in activity of default mode network: An exploratory study. Lubomira Novakova, Martin Gajdos, & Irena Rektorova. Brain Stimulation. January 2020
- The role of the anterior intraparietal sulcus and the lateral occipital cortex in fingertip force scaling and weight perception during object lifting. Vonne van Polanen, Guy Rens, & Marco Davare. bioRxiv. December 2019
- Restoring tactile sensations via neural interfaces for real-time force-and-slippage closed-loop control of bionic hands. Loredana Zollo, Giovanni Di Pino, Anna L. Ciancio, Federico Ranieri, Francesca Cordella, Cosimo Gentile, Emiliano Noce, Rocco A. Romeo, Alberto Dellacasa Bellingegni, Gianluca Vadalà, Sandra Miccinilli, Alessandro Mioli [...] and Eugenio Guglielmelli. Science Robotics. February 2019
- Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease. Lubos Brabenec, Patricia Klobusiakova, Marek Barton, Jiri Mekysk, Zoltan Galaz, Vojtech Zvoncak, Tomas Kiska, Jan Mucha, Zdenek Smekal, Milena Kostalova, & Irena Rektorova. Parkinsonism & Related Disorders. October 2018
- Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion. Alessandro Mioli, Marco D’Alonzo, Giovanni Pellegrino, Domenico Formica, and Giovanni Di Pino. Frontiers in Neuroscience. 2018
- Combining Robotic Training and Non-Invasive Brain Stimulation in Severe Upper Limb-Impaired Chronic Stroke Patients. Vincenzo Di Lazzaro, Fioravante Capone, Giovanni Di Pino, Giovanni Pellegrino, Lucia Florio, Loredana Zollo, Davide Simonetti, Federico Ranieri, Nicoletta Brunelli, Marzia Corbetto, Sandra Miccinilli, Marco Bravi, & Stefano Milighet. Frontiers in Neuroscience. October 2016
- Recognition and Processing of Visual Information after Neuronavigated Transcranial Magnetic Stimulation Session. Wiktoria Kasprzycka, Magdalena Ligia Naurecka, Bartosz Michał Sierakowski, Paulina Putko, Zygmunt Mierczyk, Grzegorz Chabik, Stanisław Dec, Stefan Gaździński and Rafał Rola. Brain Sciences. September 2022
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops
