Elevate TMS

The Elevate TMS controllable pulse parameter TMS (cTMS) system provides the user with unprecedented control and freedom to modify and adapt all aspects of their TMS pulse width and shape.

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DuoMag XT

Elevate TMS

Based on revolutionary controllable pulse parameter TMS (cTMS) technology, Elevate TMS gives you unprecedented control and freedom to modify and adapt your TMS pulse width and shape, and allows the amplitude of the second, negative phase of biphasic TMS pulses to be altered relative to the earlier, positive phase. 

These new controllable pulse parameters are crucial in allowing researchers to explore how TMS interacts with the brain at the neuronal level, as well as providing a robust, reproducible excitatory or inhibitory effect.

Elevate TMS’ instrument design is inspired by novel work carried out by Dr Angel Peterchev while at Columbia University, and features a unique system architecture consisting of two capacitors and a sophisticated switching system.

Unlike traditional TMS devices, Elevate TMS is able to repetitively generate near-rectangular electric field pulses at high frequencies (up to 1kHz) and allows for direct control over pulse width, shape, amplitude and directionality.

WHOLLY CUSTOMISABLE PULSE SHAPES

Thanks to the unique system architecture, the Elevate TMS can deliver a myriad TMS pulses. All aspects of the TMS pulse can be manipulated for the specific targeting of different neuron populations. The ability to change both the width and the shape of a TMS pulse allows the researcher to explore an unprecedented amount of options. Biphasic, polyphasic, staircase, and asymmetric pulse shapes can be delivered as unidirectional and biphasic rTMS, theta-burst and quadripulse protocols.

INTUITIVE CONTROLS

A large touch screen interface is used to control the Elevate TMS. All parameters, including type of stimulation, setting the pulse shape and controlling the M-Ratio is hosted on the Elevate TMS propriety software.

MULTIPLE COILS

A range of ElevateTMS-compatible coils with low, medium, and high inductances are offered by Rogue Research.

Pulse directionality

Control amplitude of -ve phase relative to the +ve phase

Pulse width

Variable; up to 385µs

Repetition rate

Up to 1 kHz

Charging power

2 x 1500 Joules per second

Triggers

4 input, 4 output, switch in, TTL out

External control

Via network

User interface

Large, capacitive touch screen

  1. Pulse width biases the balance of excitation and inhibition recruited by transcranial magnetic stimulation. Ricci Hannah, Lorenzo Rocchi, Sara Tremblay, Eleanor Wilson, & John C. Rothwell. Brain Stimulation. May 2020
  2. Longer cTMS pulse width switches 1 Hz inhibitory motor cortex rTMS aftereffects to excitation. I. Halawa, Y. Shirota, A. Neef, M. Sommer, & W. Paulus. Brain Stimulation. March 2019
  3. Effects of pulse width, waveform and current direction in the cortex: A combined cTMS-EEG study. Casula EP, Rocchi L, Hannah R, & Rothwell JC. Brain Stimulation. October 2018
  4. TMS of primary motor cortex with a biphasic pulse activates two independent sets of excitable neurones. Sommer M, Ciocca M, Chieffo R, Hammond P, Neef A, Paulus W, Rothwell JC, & Hannah R. Brain Stimulation. May 2018
  5. Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation. Goetz SM, Luber B, Lisanby SH, Murphy DL, Kozyrkov IC, Grill WM, & Peterchev AV. Brain Stimulation. January 2016
  6. Strength-Duration Relationship in Paired-pulse Transcranial Magnetic Stimulation (TMS) and Its Implications for Repetitive TMS. Shirota Y, Sommer M, & Paulus W. Brain Stimulation. September 2016
  7. Effect of coil orientation on strength–duration time constant and I-wave activation with controllable pulse parameter transcranial magnetic stimulation. Kevin D’Ostilio, Stefan M.Goetz, Ricci Hannah, Matteo Ciocca, Raffaella Chieffo, Jui-Cheng A. Chen, Angel V. Peterchev, & John C. Rothwell. Clinical Neurophysiology. January 2016

Compatible Products

This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.

Associated Techniques

To find out more about the techniques that are applicable to this product, follow the links below.

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Training
Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Collaboration
Grant Applications, Industrial Projects, Workshops

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