Elevate TMS (cTMS)
Based on revolutionary controllable pulse parameter TMS (cTMS) technology, Elevate TMS gives you unprecedented control and freedom to modify and adapt your TMS pulse width and shape, and allows the amplitude of the second, negative phase of biphasic TMS pulses to be altered relative to the earlier, positive phase.
These new controllable pulse parameters are crucial in allowing researchers to explore how TMS interacts with the brain at the neuronal level, as well as providing a robust, reproducible excitatory or inhibitory effect.
Elevate TMS’ instrument design is inspired by novel work carried out by Dr Angel Peterchev while at Columbia University and features a unique system architecture consisting of two capacitors and a sophisticated switching system.
Unlike traditional TMS devices, Elevate TMS is able to repetitively generate near-rectangular electric field pulses at high frequencies (up to 1kHz) and allows for direct control over pulse width, shape, amplitude and directionality.
Intuitive Controls & User Interface
The Elevate TMS system features an intuitive and user-friendly, touch-screen interface that allows for quick and precise adjustments of the desired pulse parameters and paradigms for your research.
Variety of Coil Designs & Options Available
All coils for the Elevate TMS system feature removable coil handles, allowing researchers to change the configuration to suit all preferences.
All coils include different inductances to extend the cTMS pulse range offered by the Elevate TMS system. Built-in coil tracker mounts also mean the Elevate TMS system can integrate seamlessly with the Brainsight TMS Navigation software for neuronavigated TMS sessions.
For researchers using computational modelling techniques, the B-Field for the Elevate TMS coil has been fully 3D mapped for use in E-field modelling research.
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WHOLLY CUSTOMISABLE PULSE SHAPES
INTUITIVE CONTROLS
MULTIPLE COILS
Pulse directionality |
Control amplitude of -ve phase relative to the +ve phase |
---|---|
Pulse width |
Variable; up to 385µs |
Repetition rate |
Up to 1 kHz |
Charging power |
2 x 1500 Joules per second |
Triggers |
4 input, 4 output, switch in, TTL out |
External control |
Via network |
User interface |
Large, capacitive touch screen |
- Pulse width biases the balance of excitation and inhibition recruited by transcranial magnetic stimulation. Ricci Hannah, Lorenzo Rocchi, Sara Tremblay, Eleanor Wilson, & John C. Rothwell. Brain Stimulation. May 2020
- Longer cTMS pulse width switches 1 Hz inhibitory motor cortex rTMS aftereffects to excitation. I. Halawa, Y. Shirota, A. Neef, M. Sommer, & W. Paulus. Brain Stimulation. March 2019
- Effects of pulse width, waveform and current direction in the cortex: A combined cTMS-EEG study. Casula EP, Rocchi L, Hannah R, & Rothwell JC. Brain Stimulation. October 2018
- TMS of primary motor cortex with a biphasic pulse activates two independent sets of excitable neurones. Sommer M, Ciocca M, Chieffo R, Hammond P, Neef A, Paulus W, Rothwell JC, & Hannah R. Brain Stimulation. May 2018
- Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation. Goetz SM, Luber B, Lisanby SH, Murphy DL, Kozyrkov IC, Grill WM, & Peterchev AV. Brain Stimulation. January 2016
- Strength-Duration Relationship in Paired-pulse Transcranial Magnetic Stimulation (TMS) and Its Implications for Repetitive TMS. Shirota Y, Sommer M, & Paulus W. Brain Stimulation. September 2016
- Effect of coil orientation on strength–duration time constant and I-wave activation with controllable pulse parameter transcranial magnetic stimulation. Kevin D’Ostilio, Stefan M.Goetz, Ricci Hannah, Matteo Ciocca, Raffaella Chieffo, Jui-Cheng A. Chen, Angel V. Peterchev, & John C. Rothwell. Clinical Neurophysiology. January 2016
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops