k-Plan Ultrasound Therapy Planning

k-Plan is an advanced modelling tool for precision planning of transcranial ultrasound procedures.

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k-Plan Ultrasound Therapy Planning

k-Plan Ultrasound Therapy Planning

What is k-Plan?

Designed for use with transcranial ultrasound stimulation (TUS) techniques, k-Plan is an advanced modelling tool for precision planning of TUS procedures. k-Plan uses a streamlined and intuitive workflow that allows users to select an ultrasound device, position the device using a template or medical image, and specify the sonication parameters.

High-resolution calculations of the ultrasound field and temperature inside the skull and brain are then automatically calculated in the cloud with a single click. No knowledge of numerical modelling or high-performance computing is required.

k-Plan Interface

User-Driven, Research Built

k-Plan is developed by researchers at University College London and the Brno University of Technology based on more than a decade of cutting-edge research into ultrasound modelling and planning for transcranial ultrasound therapy. More than just a research tool, k-Plan features a refined UI/UX shaped by extensive formative user testing. Features like transducer click-to-place, configurable image overlays, and traceable reporting reduce setup time and increase productivity when running simulations. 

Study Management

k-Plan integrates a complete study management system. Users can capture study information, subject details, and study IDs according to study requirements, and then later de-identify or anonymise planning simulations with a single click. 

k-Plan Study Management

Expandable Transducer Library

k-Plan can model single element, annular array, and multi-element transducers. The transducer library is user-extendable to model transducers from a wide range of manufacturers or custom transducer designs. 

Intelligent Compute Engine

k-Plan’s intelligent compute engine completely automates the process of running a planning simulation for transcranial ultrasound therapy. It automatically maps from skull images to material properties, generates an accurate model of the transducer based on geometric and calibration information, and then sets appropriate numerical and computational parameters. Simulation outputs are automatically processed to display the ultrasound field and temperature inside the brain, and to calculate exposure and dose parameters. 

State-of-the-Art Simulation Tool

Behind the scenes, k-Plan runs simulations using k-Wave, a state-of-the-art simulation tool that is widely used across academia and industry to study acoustic wave propagation. It uses an experimentally validated full-wave acoustic model to accurately calculate how ultrasound waves travel from a therapy device through the skull and into the brain. This is coupled with a model of heat diffusion and perfusion to calculate temperature rise and thermal dose. 

k-Plan Simulation

Cloud-based Planning Simulations

k-Plan allows access to high-performance computing resources in the cloud to run high-resolution planning simulations with a single click. The simple installation procedure and intuitive workflow means users can be running simulations within minutes, with no additional resources or accounts required. k-Plan’s automated dispatch server optimises the computing resources needed for every simulation, minimising the time between planning and results. The status of running simulations is automatically refreshed and displayed in the plan browser.

Optimised Targetting

Alignment of the ultrasound beam with the brain target can be iteratively optimised by adjusting the transducer position and sonication parameters and comparing the calculated exposure and dose parameters. For multi-element transducers, automated correction for skull aberrations can also be performed to precisely target the desired brain area. 

k-Plan Targetting

Workflow Integration

k-Plan easily integrates into standard neurostimulation workflows, including importing and exporting transducer positions for use with neuronavigation systems, exporting sonication parameters to therapy devices, and exporting traceable plan reports. 

Flexible Skull Mapping

k-Plan relies on a skull image to compute the ultrasound and temperature fields inside the brain. While x-ray computed tomography (CT) images currently provide the gold standard, k-Plan is also configured to work with MR-based skull segmentations and MR skull imaging techniques such as zero-echo time (ZTE) imaging. 

Flexible Skull Mapping

Secure by Design

Subject data is stored in a password protected AES-256 encrypted database stored locally with each installation. Only anonymised data is transferred to the cloud using industry-standard encrypted communication protocols along with advanced data security and integrity measures. To accommodate data privacy laws in different jurisdictions, the cloud computing resources used by k-Plan can also be restricted to geographical regions 

Advanced Web Portal

k-Plan’s advanced web portal provides a complete snapshot of your account, including current cloud computing allocations, and a complete usage history. Self-service options allow administrative users to add or remove accounts associated with the same software license and modify user privileges. 

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Cloud-Based Planning Stimulations

By making use of powerful cloud computing techniques, k-Plan is able to run high-resolution planning simulations with a single click.

Expandable Transducer Library

Model single element, annular array, and multi-element phase-array transducers with k-Plan

Safe & Secure Data

k-Plan's data is stored locally in a password-protected, encrypted database. k-Plan will only ever transfer anonymised data for cloud computing purposes.

Expert Design

k-Plan has been developed by expert researchers at University College London and the Brno University of Technology: leading institutes in transcranial focused ultrasound stimulation research.

Advanced Planning Made Accessible

k-Plan's advanced modelling tools are calculated with a single click, and no knowledge of numerical modelling or high performance computing is required.

Network Requirements

Internet

k-Plan requires a reliable internet connection

 

Hardware/Software Requirements

Graphics

2GB graphics memory or more (recommended)

Display

1280 x 1024 (minimum), 1920 x 1200 (recommended)

Operating System

Windows 10

Hard Drive

2GB free space (minimum), 20GB free space (recommended, for storage of plans)

Compatible Products

This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.

Associated Techniques

To find out more about the techniques that are applicable to this product, follow the links below.

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Training
Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Collaboration
Grant Applications, Industrial Projects, Workshops

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