
neuroConn LOOP-IT
The neuroConn LOOP-IT device features a hardware platform perfect for scientific closed-loop experiments. The device provides a minimised constant delay between data acquisition, event detection, analysis and derived parameters for the output module (for example: current source).
Electrically Independent Modules
The closed-loop device supports a number of state-of-the-art features, including supporting a combination of electrically independent modules with different functionalities such as EEG/ECG/EMG biosignal acquisition (up to 16 ksps), tDCS / tACS / tRNS current sources (low noise, > 5mAPP, >5 kHz bandwidth), multichannel digital I/O (for tES and TMS), interface for active electrodes, sensor interface for non-electrical bio signals (e.g. pressure, breathing, blood flow, temperature), and evoked potential and display interface (e.g. for feedback applications).
REAL-TIME data Processing Platform
The LOOP-IT closed-loop device platform is based on real-time data processing with all modules running synchronised, simultaneous read/write access to all modules, and jitter-free data transcribing, as well as a loop delay that can be set down to 100 μs.

LOOP IT FES

The LOOP-IT FES device is an enhanced version of the LOOP-IT, still designed to enable and support closed-loop scientific experiments for tES, but with the addition of highly synchronised transcranial, peripheral and paired-associative closed-loop experiments(FES/NMES). The system has been developed for high-precision neuroscience and neurorehabilitation research which combines brain and muscle modulation in a single system.
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MODULAR DESIGN
The LOOP-IT's modular design enables the system to be used with endless combinations of electrically isolated analogue and digital I/O modules.
SUPER-FAST PROCESSING
LOOP-IT provides real-time algorithms for closed-loop NIBS-EEG research. This means that it is capable of super-fast processing within 1 ms, with no forward prediction (extrapolation) necessary.
LOW-COST SOLUTION
The neuroConn LOOP-IT is a low-cost, all-in-one platform for closed loop NIBS-EEG.
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Stimulation - tES
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Number of channels
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2 pairs (2 anode, 2 cathode)
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Stimulation modes
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TIF or tDCS, tACS, tRNS
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Stimulation current
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5 mApp
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Bandwidth
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5kHz
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| Stimulation - FES |
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Number of channels
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2 pairs (2 anode and 2 cathode)
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Stimulation modes
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FES, NMES, TMS
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Stimulation current
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max. 200 mApp and < 2 μs rise time
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Bandwidth
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up to 300 kHz
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Recording - EXG
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Number of channels
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8 (EEG, EMG, ECG)
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Sampling rate
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24 bit / 1 kHz
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Adjustable dynamic range
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±2.5V … ±104mV
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Interface types
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USB, TCP/IP, RS232, TTL
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Number of channels (TTL)
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2 input / 2 output
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- NeuroSimo: An open-source software for closed-loop EEG- or EMG-guided TMS [preprint]. Kahilakoski, O.-P., Alkio, K., Siljamo, O., Valén, K., Laurinoja, J., Haxel, L., Makkonen, M., Mutanen, T. P., Tommila, T., Guidotti, R., Pieramico, G., Ilmoniemi, R. J., & Roine, T. (2025). bioRxiv.
- Phase-specific stimulation of the human brain with real-time measurement instead of prediction [preprint]. Guggenberger, R., Gebühr, J.-S., Keute, M., & Gharabaghi, A. (2023). bioRxiv.
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Associated Techniques
To find out more about the techniques that are applicable to this product, follow the links below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops





