NeuroFUS PRO

The NeuroFUS PRO system for Transcranial-focused ultrasound neuromodulation (TUS/tFUS) offers unprecedented spatial resolution and adjustable focus, allowing for unparalleled depth of non-invasive transcranial brain or transdermal nerve modulation versus other methods of non-invasive brain stimulation.

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NeuroFUS PRO

NeuroFUS PRO

The NeuroFUS PRO system is a complete, laboratory-ready system that can be used to administer low-intensity, pulsed transcranial ultrasound stimulation (TUS/tFUS/FUS) to the brain. 

What is Transcranial Focused Ultrasound Stimulation?

Transcranial-focused ultrasound stimulation (sometimes referred to as Transcranial-focused ultrasound neuromodulation) is a non-invasive means of brain stimulation that uses low-intensity sound waves (ultrasound) to temporarily affect or alter brain activity in a subject.

TUS offers unprecedented spatial resolution and depth of focus versus other methods of non-invasive brain stimulation - such as TMS, tES, or DBS - and has been shown to be a safe and effective method of delivering precise ultrasonic energy to the brain without causing tissue damage or lasting neurological effects.

Read a full introduction to Transcranial-focused ultrasound stimulation here.

A demonstration of the NeuroFUS system in action:

What can NeuroFUS offer my research?

The NeuroFUS PRO delivers transcranial (tFUS/TUS) or peripheral focused ultrasound (pFUS) waveforms for the modulation of neuronal activity at a high resolution. Transcranial-focused ultrasound stimulation works in a similar way to transcranial magnetic stimulation (TMS) but uses low-intensity pulsed ultrasound (LIFU) in place of magnetic pulses. As a result, NeuroFUS offers significantly higher spatial resolution and is capable of reaching deeper brain regions vs other methods of non-invasive brain stimulation. 

Ultimate Flexibility in Study Design

The NeuroFUS PRO system is electromagnetically and mechanically compatible with an extensive range of modern neuroscience research methods and neurotechnologies, including:

  • Human behaviour;
  • Optical imaging (including techniques such as fNIRS);
  • Electroencephalography (EEG);
  • Augmented Reality and/or Virtual Reality immersion/stimulation;
  • Peripheral nerve stimulation (including Vagus Nerve Stimulation (VNS));
  • Brain-computer interfaces (BCIs);
  • Computational modelling techniques;
  • and other traditional neuromodulation methods such as tES, tDCS, tACS, and TMS.

NeuroFUS' integration with a wide range of complementary technologies offers researchers the possibility of carrying out truly advanced multimodal neuroscience projects.

The NeuroFUS is intended as a TUS/FUS research system and has not yet been certified as a medical device.

What is Transcranial Focused Ultrasound Neuromodulation?

Transcranial-focused ultrasound is an innovative new form of neuromodulation that uses low-intensity sound waves to temporarily affect or alter brain activity.

TUS offers unprecedented spatial resolution and depth of focus versus other methods of non-invasive brain stimulation (such as TMS, tES, or DBS), and has been shown to be a safe and effective method of delivering precise ultrasonic energy to the brain without causing tissue damage or lasting neurological effects.

An Introduction to Transcranial Ultrasound Stimulation:

Dr Lennart Verhagen (Donders Institute) provides an introduction to TUS research techniques in this Brainbox Initiative webinar.

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ACCOMPANYING SOFTWARE DEVELOPMENT KIT

The NeuroFUS PRO's Software Development Kit (SDK) provides users with the option to choose from a number of preset, approved neuromodulation pulse sequences contributed by TUS researchers around the world.

TOTAL SAFETY AND COMFORT OF OPERATION

The NeuroFUS PRO comes complete with a range of peripheral safety equipment for ultimate peace of mind and safety during your TUS research, including:

• RFWattmeter monitoring, with inbuilt automatic system shutdown capabilities
• Floating ground transducer casing, hi-pot tested to pass 2MOPP
• Peak and average power limiting systems
• An ergonomic system handle, and a solid water-free coupling bolus to reduce strain on the operator

TRANSDUCER POWER OUTPUT ELECTRONICS

The NeuroFUS PRO is powered by Sonic Concepts, Inc.’s Transducer Power Output drive electronics, commander USB interface and focused annular array transducer technology, and each system is provided fully calibrated with the relevant Certificate of Conformance.

FULL TRAINING & SUPPORT

Each NeuroFUS PRO order is supplemented with an inclusive workshop registration, training sessions, and neuromodulation research consultation.

 

CTX-250

CTX-500

CTX-1000

uTX-2500

Centre Frequency, MHz

0.25

0.50

1.00

2.50

Peak Power, W

16.85

4.00

0.95

0.08

Total Acoustic Power, W

14.3

3.4

0.8

0.1

Distance to Focus, mm

40

52

52

13

Focal Intensity - free field, W/cm2

30

30

30

30

Focal Intensity - 2.7dB/cm derated, W/cm2

16.1

5.9

1.2

4.0

Focal Lateral Width, mm (diameter)

6.45

3.14

1.53

0.46

Focal Axial Length, mm

43.99

23.04

11.53

2.64

Grating Lobe Range, mm

40

40

40

7

Penetration Distance Minimum, mm

20

32

32

9.5

Penetration Distance Maximum, mm

60

72

72

16.5

 

Note: Listed transducer focal sizes are simulated based on ideal conditions. Actual free field performance may vary and is provided for each transducer.

  1. Toward focused ultrasound neuromodulation in deep brain stimulator implanted patients: Ex-vivo thermal, kinetic and targeting feasibility assessment. Sarica C, Fomenko A, Nankoo JF, Darmani G, Vetkas A, Yamamoto K, Lozano AM, Chen R.. Brain Stimulation. February 2022
  2. Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior. Anton Fomenko Is a corresponding author, Kai-Hsiang Stanley Chen, Jean-François Nankoo, James Saravanamuttu, Yanqiu Wang, Mazen El-Baba, Xue Xia, Shakthi Sanjana Seerala, Kullervo Hynynen. ELife. November 2020
  3. Neuronavigated Repetitive Transcranial Ultrasound Stimulation Induces Long-Lasting and Reversible Effects on Oculomotor Performance in Non-human Primates. Pierre Pouget, Stephen Frey, Harry Ahnine1, David Attali, Julien Claron, Charlotte Constans, Jean-Francois Aubry and Fabrice Arcizet. Frontiers in Physiology. August 2020
  4. Remote, brain region–specific control of choice behavior with ultrasonic waves. Jan Kubanek1, Julian Brown, Patrick Ye, Kim Butts Pauly, Tirin Moore and William Newsome. ScienceAdvances. May 2020
  5. Effect Of Low-intensity Pulsed Ultrasound On Epileptiform Discharges In A Penicillin-induced Epilepsy Model In Non-human Primates. J. Zou, Y. Guo, L. Niu, L. Meng, N. Pang, H. Zheng. Brain Stimulation. March 2019
  6. Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation. Davide Folloni, Lennart Verhagen, Rogier B Mars, Elsa Fouragnan, Charlotte Constans, Jean-François Aubry, Matthew F S Rushworth, Jérôme Sallet. Neuron. March 2019
  7. Offline impact of transcranial focused
    ultrasound on cortical activation in
    primates
    . Lennart Verhagen [. . .] Jerome Sallet. ELife. February 2019
  8. Real-time imaging of brain displacement during FUS neuromodulation in rodents in vivo. Tara Kugelman, Mark T. Burgess, Elisa Konofagou. The Journal of the Acoustical Society of America. 2019
  9. Neuromodulation of sensory
    networks in monkey brain by
    focused ultrasound with MRI
    guidance and detection
    . Pai-Feng Yang, M. Anthony Phipps, Allen T. Newton, Vandiver Chaplin, John C. Gore,
    Charles F. Caskey, & Li Min Chen. Scientific Reports. May 2018
  10. Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task. Nicolas Wattiez, Charlotte Constans, Thomas Deffieux, Mickael Tanter, Jean-François Aubry, Pierre Pouget. Brain Stimulation. November 2017

Associated Techniques

To find out more about the techniques that are applicable to this product, follow the links below.

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Training
Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Collaboration
Grant Applications, Industrial Projects, Workshops

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