The NeuroFUS PRO system for Transcranial-focused ultrasound neuromodulation (TUS/tFUS) offers unprecedented spatial resolution and adjustable focus, allowing for unparalleled depth of non-invasive transcranial brain or transdermal nerve modulation versus other methods of non-invasive brain stimulation.
NeuroFUS PRO
The NeuroFUS PRO system is a complete, laboratory-ready system that can be used to administer low-intensity, pulsed transcranial ultrasound stimulation (TUS/tFUS/FUS) to the brain.
What is Transcranial Ultrasound Stimulation?
Transcranial ultrasound stimulation (sometimes referred to as Transcranial-focused ultrasound stimulation and Transcranial-focused ultrasound neuromodulation) is a non-invasive means of brain stimulation that uses low-intensity sound waves (ultrasound) to temporarily affect or alter brain activity in a subject.
TUS offers unprecedented spatial resolution and depth of focus versus other methods of non-invasive brain stimulation - such as TMS, tES, or DBS - and has been shown to be a safe and effective method of delivering precise ultrasonic energy to the brain without causing tissue damage or lasting neurological effects.
Read a full introduction to Transcranial-focused ultrasound stimulation here.
A demonstration of the NeuroFUS system in action:
What can NeuroFUS offer my research?
The NeuroFUS PRO delivers transcranial (tFUS/TUS) or peripheral-focused ultrasound (pFUS) waveforms for the modulation of neuronal activity at a high resolution. Transcranial- ultrasound stimulation works in a similar way to transcranial magnetic stimulation (TMS) but uses low-intensity pulsed ultrasound (LIFU) in place of magnetic pulses. As a result, NeuroFUS offers significantly higher spatial resolution and is capable of reaching deeper brain regions vs other methods of non-invasive brain stimulation.
Ultimate Flexibility in Study Design
The NeuroFUS PRO system is electromagnetically and mechanically compatible with an extensive range of modern neuroscience research methods and neurotechnologies, including:
- Human behaviour;
- Optical imaging (including techniques such as fNIRS);
- Electroencephalography (EEG);
- Augmented Reality and/or Virtual Reality immersion/stimulation;
- Peripheral nerve stimulation (including Vagus Nerve Stimulation (VNS));
- Brain-computer interfaces (BCIs);
- Computational modelling techniques;
- and other traditional neuromodulation methods such as tES, tDCS, tACS, and TMS.
NeuroFUS' integration with a wide range of complementary technologies offers researchers the possibility of carrying out truly advanced multimodal neuroscience projects.
The NeuroFUS is intended as a TUS/FUS research system and has not yet been certified as a medical device.
What is Transcranial Focused Ultrasound Neuromodulation?
Transcranial-focused ultrasound is an innovative new form of neuromodulation that uses low-intensity sound waves to temporarily affect or alter brain activity.
TUS offers unprecedented spatial resolution and depth of focus versus other methods of non-invasive brain stimulation (such as TMS, tES, or DBS), and has been shown to be a safe and effective method of delivering precise ultrasonic energy to the brain without causing tissue damage or lasting neurological effects.
An Introduction to Transcranial Ultrasound Stimulation:
Dr Lennart Verhagen (Donders Institute) provides an introduction to TUS research techniques in this Brainbox Initiative webinar.
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TOTAL SAFETY AND COMFORT OF OPERATION
The NeuroFUS PRO comes complete with a range of peripheral safety equipment for ultimate peace of mind and safety during your TUS research, including:
• RFWattmeter monitoring, with inbuilt automatic system shutdown capabilities
• Floating ground transducer casing, hi-pot tested to pass 2MOPP
• Peak and average power limiting systems
• An ergonomic system handle, and a solid water-free coupling bolus to reduce strain on the operator
TRANSDUCER POWER OUTPUT ELECTRONICS
The NeuroFUS PRO is powered by Sonic Concepts, Inc.’s Transducer Power Output drive electronics, commander USB interface and focused annular array transducer technology, and each system is provided fully calibrated with the relevant Certificate of Conformance.
AXIAL STEERING
With a multi-element design that allows axial steering, the NeuroFUS PRO enables unparalleled precision in targeting specific brain regions. The system allows for focal steering between 25mm and 125mm by using an annual array, providing flexibility in delivering ultrasound waves.
SEEMLESS INTEGRATIONS
The NeuroFUS PRO turnkey solution integrates seamlessly with neuronavigation systems such as Brainsight Neuronavigation, allowing for real-time visualisation of ultrasound targeting, K-Plan for intuitive and precise ultrasound planning, and includes a feature full, easy to use graphical user interface for complete control of the system.
COMPATABILITY
The NeuroFUS PRO system offers complete compatibility with TMS, EEG, and NIRS modalities, as well as an option for MR compatibility, providing integration with neuroimaging and brain stimulation techniques seamlessly.
|
|
CTX-250-4CH |
CTX-500-4CH |
CTX-1000-4CH |
uTX-2500 |
|---|---|---|---|---|
|
Centre Frequency, MHz |
0.25 |
0.50 |
1.00 |
2.50 |
|
Peak Power, W |
16.85 |
4.00 |
0.95 |
0.08 |
|
Total Acoustic Power, W |
14.3 |
3.4 |
0.8 |
0.1 |
|
Distance to Focus, mm |
40 |
52 |
52 |
13 |
|
Focal Intensity - free field, W/cm2 |
30 |
30 |
30 |
30 |
|
Focal Intensity - 2.7dB/cm derated, W/cm2 |
16.1 |
5.9 |
1.2 |
4.0 |
|
Focal Lateral Width, mm (diameter) |
6.45 |
3.14 |
1.53 |
0.46 |
|
Focal Axial Length, mm |
43.99 |
23.04 |
11.53 |
2.64 |
|
Grating Lobe Range, mm |
40 |
40 |
40 |
7 |
|
Penetration Distance Minimum, mm |
20 |
25 |
40 |
9.5 |
|
Penetration Distance Maximum, mm |
60 |
60 |
60 |
16.5 |
Note: Listed transducer focal sizes are simulated based on ideal conditions. Actual free field performance may vary and is provided for each transducer.
- Toward focused ultrasound neuromodulation in deep brain stimulator implanted patients: Ex-vivo thermal, kinetic and targeting feasibility assessment. Sarica C, Fomenko A, Nankoo JF, Darmani G, Vetkas A, Yamamoto K, Lozano AM, Chen R.. Brain Stimulation. February 2022
- Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior. Anton Fomenko Is a corresponding author, Kai-Hsiang Stanley Chen, Jean-François Nankoo, James Saravanamuttu, Yanqiu Wang, Mazen El-Baba, Xue Xia, Shakthi Sanjana Seerala, Kullervo Hynynen. ELife. November 2020
- Neuronavigated Repetitive Transcranial Ultrasound Stimulation Induces Long-Lasting and Reversible Effects on Oculomotor Performance in Non-human Primates. Pierre Pouget, Stephen Frey, Harry Ahnine1, David Attali, Julien Claron, Charlotte Constans, Jean-Francois Aubry and Fabrice Arcizet. Frontiers in Physiology. August 2020
- Remote, brain region–specific control of choice behavior with ultrasonic waves. Jan Kubanek1, Julian Brown, Patrick Ye, Kim Butts Pauly, Tirin Moore and William Newsome. ScienceAdvances. May 2020
- Effect Of Low-intensity Pulsed Ultrasound On Epileptiform Discharges In A Penicillin-induced Epilepsy Model In Non-human Primates. J. Zou, Y. Guo, L. Niu, L. Meng, N. Pang, H. Zheng. Brain Stimulation. March 2019
- Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation. Davide Folloni, Lennart Verhagen, Rogier B Mars, Elsa Fouragnan, Charlotte Constans, Jean-François Aubry, Matthew F S Rushworth, Jérôme Sallet. Neuron. March 2019
- Offline impact of transcranial focused
ultrasound on cortical activation in
primates. Lennart Verhagen [. . .] Jerome Sallet. ELife. February 2019 - Real-time imaging of brain displacement during FUS neuromodulation in rodents in vivo. Tara Kugelman, Mark T. Burgess, Elisa Konofagou. The Journal of the Acoustical Society of America. 2019
- Neuromodulation of sensory networks in monkey brain by focused ultrasound with MRI guidance and detection. Pai-Feng Yang, M. Anthony Phipps, Allen T. Newton, Vandiver Chaplin, John C. Gore,
Charles F. Caskey, & Li Min Chen. Scientific Reports. May 2018 - Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task. Nicolas Wattiez, Charlotte Constans, Thomas Deffieux, Mickael Tanter, Jean-François Aubry, Pierre Pouget. Brain Stimulation. November 2017
- Disentangling transcranial and auditory sources of the transcranial ultrasonic stimulation induced suppression of corticospinal excitability. Tulika Nandi, Umair Hassan, Melissa Null, Angela Radetz, Til Ole Bergmann. Brain Stimulation, VOLUME 16, ISSUE 1, P201. January 2023
- Ramped V1 transcranial ultrasonic stimulation modulates but does not evoke visual evoked potentials. Tulika Nandi, Ainslie Johnstone, Eleanor Martin, Catharina Zich, Robert Cooper, Sven Bestmann, Til Ole Bergmann, Bradley Treeby, Charlotte J. Stagg. Brain Stimulation, VOLUME 16, ISSUE 2, P553-555. March 2023
- Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans. Siti N. Yaakub, Tristan A. White, Jamie Roberts, Eleanor Martin, Lennart Verhagen, Charlotte J. Stagg, Stephen Hall & Elsa F. Fouragnan. Nature Communications, 14(1). September 2023
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Associated Techniques
To find out more about the techniques that are applicable to this product, follow the links below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops
