NeuroFUS PRO

Steerability: Advanced Focal Steering for Precise Targeting

The NeuroFUS system leverages a multi-channel, multi-element design that allows axial steering, enabling unparalleled precision in targeting specific brain regions. Using annular array transducers, the NeuroFUS system allows for focal steering between 25mm and 125mm, providing flexibility in delivering ultrasound waves. By controlling the phase angle and power to each transducer, users can adjust the focus and intensity with high accuracy, ensuring precise neuromodulation.

Turnkey Solution: Seamless Integration

The NeuroFUS system is a turnkey solution that integrates seamlessly with neuronavigation systems such as Brainsight Neuronavigation, allowing for real-time visualisation of ultrasound targeting. The intuitive graphical user interface (GUI) ensures smooth and precise control over the system, while the integration with ultrasound planning tools such as K-Plan simplifies the planning and execution of complex stimulation protocols. This makes the NeuroFUS ideal for research settings where accuracy and continuity are paramount.

Built-In Power Monitoring and Safety Features

The NeuroFUS system is equipped with built-in power monitoring capabilities. The system directly measures electrical output power in watts, ensuring accurate delivery of ultrasound. As well as featuring an automatic shutdown mechanism to prevent sonication in the air, further enhancing user and patient safety.

For continuous quality assurance, the NeuroFUS Tracer provides a mechanism to verify the transducer's output. Utilising a hydrophone, this allows users to check the calibration and ensure that the transducer delivers the correct parameters. Overtime, this allows users to maintain peak performance and accurate results by monitoring the output in comparison to its previous calibration.

Compatibility and Modality Integration

MRI-Compatible Package

The NeuroFUS system is designed to work within the challenging environment of an MRI suite, where high RF fields and impedance issues are common. By using an innovative transducer matching network and specialised cables, the NeuroFUS can operate within the MRI environment without sacrificing performance. The system offers compatibility with TMS, EEG, and NIRS modalities, providing the ability to integrate neuroimaging and brain stimulation techniques seamlessly.

Multi-Planar Targeting

Thanks to the dual-transducer design, the NeuroFUS allows for multi-planar targeting. Using two 4-channel transducers, users can perform crossbeam targeting, focusing ultrasound on small, specific areas of the brain, enhancing the precision of stimulation.

Control and Customisation

The NeuroFUS system includes multiple control options, allowing researchers the flexibility to customise and program the device according to their specific needs. With a graphical user interface (GUI) and multiple triggering options available, including three trigger modes (standard and two high-speed), users can synchronise the NeuroFUS with other systems such as MRI for precise stimulation timing.

Graphical User Interface

The NeuroFUS PRO comes standard with an intuitive acquisition interface with multiple control and protocol features included, consisting of:

• Published Protocol Database - Over 100 pre-loaded protocols from published studies. Easy to reproduce and replicate previous studies made on the NeuroFUS Pro.
• Standardised Reporting - After creating a protocol, create an auto populated report in line with the ITRUSST Consensus on Standardised Reporting for Transcranial Ultrasound Stimulation 1016/j.brs.2024.04.013
• History View - Reload previously run protocols, create reports from previous protocols, view power data history.
• Real time power Monitoring – Ability to monitor the power of each channel as the protocol is running.
• Transducer Performance Test – Intuitive transducer test, reporting the constitution of the transducer over time, allowing the user to predict when a transducer needs recalibration.
• Integration with k-Plan - Load protocols relating to a k-Plan simulation.

Multiple Transducer Options

The NeuroFUS system offers versatile transducer options and advanced capabilities. With options like the CTX 250 and CTX 500 (both 2-channel) and the DPX 500 (4-channel), the system provides flexibility across various research needs. The DPX 500 transducer delivers higher frequency stimulation with focal depths from 55mm to 125mm, optimised for targeting deeper brain regions. Lower frequency options, such as the 250 kHz transducer, achieve higher skull penetration, making them ideal for high-intensity applications or large-animal studies. With a frequency range from 250 kHz to 1000 kHz and an axial steering range of 25-125mm, the NeuroFUS balances depth and spatial resolution, with higher frequencies offering precise targeting with reduced skull penetration, while lower frequencies cover larger areas more effectively. The table below compares the NeuroFUS transducer configurations focal size with their estimated derated focal intensity*.

The NeuroFUS PRO is an all-encompassing solution for advanced transcranial ultrasound stimulation. Its high precision, seamless integration with neuronavigation systems, and robust safety features make it the ideal choice for research applications. With its wide range of customisation options and compatibility with other neuromodulation technologies, NeuroFUS pro sets the standard for transcranial ultrasound stimulation.