NeuroFUS® 3D, the next generation of non-invasive focused ultrasound neuromodulation. Building on the proven performance of the NeuroFUS® PRO, this system introduces true three-dimensional beam steering, dual transducer arrays, and integrated image guidance for unmatched precision and flexibility in both preclinical and clinical research. Engineered for seamless integration and refined control, NeuroFUS 3D delivers volumetric stimulation across defined brain regions with intuitive operation and full compatibility with both MRI and ultrasound-based navigation systems. Whether for exploratory neuroscience or targeted therapeutic investigations, NeuroFUS 3D enables researchers to explore new frontiers in transcranial ultrasound stimulation (TUS).
NeuroFUS 3D
Target subcortical regions with 218 individually addressable elements. The system utilises two 109-element sparse-array transducers to deliver high-fidelity acoustic output across a 350–650 kHz operating band.
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Volumetric Steering: Adjust the focal peak electronically across a range of 2.1–13.9 cm (axial) and up to ±3.4 cm (lateral) without moving the transducer head.
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Cross-Beam Operation: Leverage the paired-head architecture to create overlapping or opposed acoustic fields for advanced neuromodulation and BBB-opening studies.
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High-Fidelity Focusing: Achieve a simulated peak focal pressure of 7.8 MPa, supported by a focal gain of approximately 9X.
Key Benefits
- True 3D beam steering for volumetric neuromodulation across defined brain regions.
- Dual transducer arrays allow flexible targeting, operate independently or combine for enhanced focal control.
- Dynamic focal steering in depth and lateral directions enables complex stimulation patterns.
- Interleaved or simultaneous targeting of multiple brain regions, including midline structures.
- Real-time acoustic verification with skull phase aberration correction.
- Dual-modality image guidance fully compatible with both MRI (MRgFUS) and ultrasound (USgFUS).
- Double-blind sham functionality using proprietary 3D dithering technology.
- Customisable stimulation protocols informed by validated TUS literature and research data.
Unified Dual-Modality Workflow
Switch between US-guided and MR-guided research without changing the acoustic source. The NeuroFUS 3D uses a single transducer head design compatible with two distinct configurations:
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Ultrasound-Guided (1.5 m): Perform bidirectional Tx/Rx operation for integrated imaging and therapeutic delivery. This broadband configuration provides an axial resolution of 2 mm for precise targeting.
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MR-Guided (10 m): Conduct investigations in bores up to 7T. This transmit-only configuration features narrowband matching, step-up autotransformers, and 60 dB Larmor attenuation to eliminate interference and artefacts at 1.5T and 3T.
Laboratory-Ready Engineering
Streamline setup with tool-free coupling. Each IP67-rated transducer head features a compact 75 mm envelope and integrated mounting holes for rapid attachment to positioners.
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Rapid Coupling: Use the front-face twist-lock guides to snap thin (<5 mm) or thick (10 mm) gel-pad assemblies into place instantly.
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Active Thermal Management: Maintain surface temperatures below 40°C during continuous duty cycles via integrated air-cooling channels within the transducer stack.
Safety and Compliance
Guarantee experimental stability with integrated safeguards. Every system is supplied with a serial-number-specific calibration report, including hydrophone pressure maps and steering verification.
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Electrical Safety: 2 MOPP insulation and 2 kV hi-pot verification ensure subject safety.
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Real-Time Monitoring: Track acoustic stack performance via integrated temperature-sensing hardware.
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MR Validated: Rigorously tested for magnetically induced displacement, torque, and RF heating at 1.5T and 3T.
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Double-blind sham stimulation
Execute rigorous scientific study designs using a proprietary 3D dithering method. This technique redistributes acoustic energy across three dimensions to preserve auditory and tactile sensations while preventing neural engagement. By maintaining total acoustic power without focal concentration, the system ensures a credible sham condition and protects data integrity.
Optimise research with a smarter, modular platform
Streamline your laboratory workflow with an intuitive graphical interface and modular architecture. The system adapts seamlessly between standalone operation and multimodal setups, supporting a wide range of experimental paradigms across both preclinical and clinical settings.
Visualise focus with full MRI compatibility
Minimise artefacts during imaging with susceptibility-neutral, non-ferrous transducer materials. The 10 m shielded cabling and integrated waveguide filtering allow the transmit module to remain safely outside the suite. Leverage MR-ARFI to visualise the acoustic focus and assess physiological responses in real time.
Verify targets with integrated ultrasound imaging
Perform skull attenuation correction and focal verification using a dedicated 256-channel verification transceiver. The system supports both pitch-catch and pulse-echo imaging techniques to ensure accurate therapeutic delivery before stimulation begins.
| Feature | Specification |
| Array Topology | Flat-face, 109-element phased array (per transducer) |
| Active Aperture | 64 mm diameter (± 0.1 mm) |
| Operating Bandwidth | 350 – 650 kHz |
| Element Count | 218 individually addressable elements (Dual-array) |
| Axial Steering Range | 2.1 – 13.9 cm (at -6 dB) |
| Lateral Steering Range | ± 3.4 cm (at -6 dB) |
| Peak Focal Pressure | 7.8 MPa (simulated at 4.5 cm focus, 500 kHz) |
| Focal Gain | ~9X (at 4.15 cm) |
| Acoustic Efficiency | ≥ 40% (calibrated electrical-in to acoustic-out) |
| Max Drive Voltage | 100 V peak (drive limited) / up to 300 V peak (element level) |
| Axial Resolution (Imaging mode) | ≤ 2 mm axial resolution at 4.25 cm focus, in the 1.5 m Tx/Rx configuration, verified on skull phantom |
| Surface Temperature | < 40 °C under continuous duty cycles |
| Ingress Protection | IP67 (transducer head immersible to 1 m) |
| MRI Compatibility | 11.5 T and 3 T, with a defined upgrade path to 7 T |
| Cabling | 1.5 m (Broadband Tx/Rx) or 10 m (Narrowband Tx-only) |
| Head Envelope | ≤ 75 mm outer diameter; ≤ 10 mm thickness |
Integration & Reliability Details
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Mechanical Interface: 3x integrated rear mounting holes for positioners and 3x front twist-lock guides for tool-free gel-pad attachment.
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Electrical Safety: 2 MOPP insulation verified to 2 kV via hi-pot testing; integrated temperature sensing for real-time stack monitoring.
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Acoustic Verification: Every system includes a per-serial-number calibration report featuring hydrophone pressure maps and steering verification.
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Coupling: Supplied with thin (<5 mm) and thick (10 mm) gel-pad variants to adjust standoff based on imaging or depth requirements.
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Associated Techniques
To find out more about the techniques that are applicable to this product, follow the links below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops
