TMS-EEG Package

The TMS-EEG-Neuronavigation package is purpose-built for synchronised brain stimulation, signal recording, and accurate targeting. The trio of systems work in concert to deliver high-quality stimulation and monitoring while maintaining an intuitive workflow for researchers.

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TMS-EEG Package

TMS-EEG Package

Includes: Duomag Mp-Dual, TruScan Research EEG, Brainsight Neuronavigation

 

The TMS-EEG-Neuronavigation Package integrates three advanced systems into a unified solution for precision-targeted brain stimulation and real-time neurophysiological monitoring:

  • TMS System: The DuoMAG MP-Dual provides fully programmable paired-pulse stimulation through a single coil, offering precise control over inter-stimulus intervals and output intensity. It's designed for research into cortical inhibition and facilitation, and ideal for probing intracortical dynamics.

  • EEG System: TruScan Research EEG streams real-time data via UDP for BCI use and accepts external triggers, supporting studies of externally-evoked post-synaptic events. Its intuitive dashboard interface and versatile review software enable easy, in-depth analysis across common formats.

  • Neuronavigation System: Brainsight TMS Navigation delivers stereotactic precision for TMS coil positioning using subject-specific MRI data. This ensures reproducibility, accuracy, and confidence in targeting cortical areas for stimulation.

Key benefits include:

  • Real-time TMS-EEG synchronisation for analysing brain responses with temporal accuracy.

  • Seamless integration of systems for direct TMS control and automated triggering within EEG software. 
  • Accurate, MRI-guided navigation to ensure targeted and reproducible TMS delivery.

Dual-Pulse Stimulation with DuoMAG MP-Dual

The DuoMAG MP-Dual allows independent control over paired pulses for advanced TMS paradigms. Adjust both timing and output intensity to investigate interhemispheric and intracortical circuits. A boosted output mode further supports demanding stimulation protocols, delivering pulses equivalent to 134% of a single stimulator’s capacity.

  • Flexible dual-pulse configuration for sub- and supra-threshold studies.

  • CE-certified system, ensuring reliability and research-grade safety.

  • Enhanced output intensity via software-based boosting for high-demand protocols.

Reliable EEG Acquisition with TruScan RE

TruScan RE offers high-fidelity EEG recordings with up to 256 channels, 12 bit TTL triggering and sampling rates up to 3000 Hz. The system’s intuitive interface ensures efficient setup, reliable operation, and high-quality data. It supports EDF+, ASCII integer, and ASCII real formats, offering broad compatibility for analysis.

  • Unrivalled TMS artefact recovery time of 2ms.
  • Accompanying acquisition software enables control of TMS intensity, pulse count, repetition rate (fixed or random), and recharge delay.
  • Modular design compatible with various sized electrode caps and electrode configurations.

Accurate Targeting with Brainsight TMS Navigation

Brainsight delivers real-time, MRI-guided navigation for precise coil placement. The system tracks coil position and orientation relative to individual anatomy, ensuring accurate, consistent stimulation across sessions and subjects.

  • Visualisation of cortical targets and stimulation pathways in 3D.

  • Intuitive, real-time feedback on coil placement and orientation.

  • Trusted by leading labs worldwide for stereotactic precision and reproducibility.

Applications in Cognitive and Clinical Neuroscience

This integrated solution supports a broad range of research applications, from probing cortical connectivity to developing targeted neuromodulation protocols for clinical research. Whether you're studying cognitive processing, mapping motor pathways, or exploring therapeutic stimulation, the TMS-EEG-Neuronavigation Package provides the flexibility and performance required to drive innovation.

With its powerful combination of targeted stimulation, real-time brain monitoring, and intuitive navigation, this package empowers researchers to investigate the brain with precision and confidence.

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Seamless Multimodal Integration

Synchronised TMS stimulation, high-resolution EEG recording, and MRI-guided coil positioning for precise brain mapping and functional connectivity research.

Programmable Dual-Pulse Stimulation

Investigate cortical inhibition and facilitation with flexible paired-pulse protocols, customisable in intensity and timing.

High-Fidelity EEG Acquisition

Real-time artifact correction, 24-bit resolution, and sampling rates up to 2000 Hz ensure clean, high-quality neurophysiological data.

Unified Workflow

Streamlined software interface and system compatibility reduce setup time and simplify data collection and analysis.

Category Specification
TMS Stimulation  
Pulse Type Monophasic paired-pulse via single coil
Inter-Stimulus Interval Fully programmable from 1 ms to 10,000 ms
Output Control Independent power level adjustment per pulse
Boosted Output Mode Equivalent to 134% of single stimulator output
Stimulation Modes Single pulse, paired-pulse, repetitive stimulation (via external triggering)
Cooling Air-cooled with coil temperature monitoring
Certification CE-certified for research use
   
EEG  
Channels 32, 64, 128, or 256 channels (expandable)
Analogue Sampling Frequency 6000 Hz
Sampling Rate of Stored Data 200, 1000, 3000 Hz
Analogue Time Constant 1s, optionally up to 10s
Maximal DC Offset ± 420 mV
IMR 160 dB
Input Impedance >20GΩ parallel to 35pF
Triggering 12 bit TTL
Power Supply Removable, rechargeable batteries. Intelligent charging arm
Data Format EDF+, ASCII Integer and ASCII Real
Compatibility Designed for simultaneous use with TMS
   
Neuronavigation  
Navigation Method Optical tracking with real-time 3D MRI co-registration
Coil Tracking Real-time feedback on coil position, angle, and distance to target
Spatial Accuracy ≤ 5 mm (typical)
Supported Imaging Formats DICOM, Analyze, NIfTI
Subject Registration Landmark, surface, and automatic MRI registration options
Workflow Integration Supports triggering and synchronisation with EEG and TMS systems
   
General Features  
Synchronisation Hardware and software integration for TMS, EEG, and Navigation
Software Control Intuitive GUI for stimulation protocols, EEG acquisition, and targeting
Export & Analysis Compatible with third-party analysis software (MATLAB, EEGLAB, FieldTrip, etc.)
Research Applications Cortical excitability, motor mapping, cognitive neuroscience, neuromodulation
  1. Unlocking adults’ implicit statistical learning by cognitive depletion. Eleonore H. M. Smalle, Tatsuya Daikoku, Arnaud Szmalec, Wouter Duyck, and Riikka Möttönen. PNAS. January 2022
  2. The interactions between Primary Somatosensory and Motor Cortex during human grasping behaviours. Madison Davis, Yiyu Wang, Shangcheng Bao, John J. Buchanan, David. L Wright, Yuming Lei.. Neuroscience. November 2021
  3. Investigation of Spatiotemporal Profiles of Single-Pulse TMS-Evoked Potentials with Active Stimulation Compared with a Novel Sham Condition. Mayuko Takano, Masataka Wada, Reza Zomorrodi, Keita Taniguchi, Xuemei Li, Shiori Honda, Yui Tobari, Yu Mimura, Shinichiro Nakajima, Ryosuke Kitahata, Masaru Mimura, Zafiris J. Daskalakis, Daniel M. Blumberger and Yoshihiro N. Biosensors. October 2022
  4. Reduced signal propagation elicited by frontal transcranial magnetic stimulation is associated with oligodendrocyte abnormalities in treatment-resistant depression. Masataka Wada, Shinichiro Nakajima, Shiori Honda, Mayuko Takano, Keita Taniguchi, Sakiko Tsugawa, Yu Mimura, Nanao Hattori, Shinsuke Koike, Reza Zomorrodi, Daniel M. Blumberger, Zafiris J. Daskalakis, Masaru Mimura and Yoshihiro Noda. Journal of Psychiatry & Neuroscience : JPN. September 2022
  5. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Dominik Pizem, Lubomira Novakova, Martin Gajdos & Irena Rektorova. Journal of Neural Transmission. 2022
  6. Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements. Kevin A. Caulfield, Holly H. Fleischmann, Claire E. Cox, Julia P. Wolf, Mark S. George, Lisa M. McTeague. Brain Stimulation. August 2022

Compatible Products

This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.

Associated Techniques

To find out more about the techniques that are applicable to this product, follow the links below.

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Training
Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Collaboration
Grant Applications, Industrial Projects, Workshops

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