Our Transcranial Ultrasound Stimulation (TUS) package combines the precision of the NeuroFUS PRO TUS System with the planning capabilities of K-Plan and seamless neuronavigation of Brainsight. This fully integrated package is designed to elevate research in non-invasive brain stimulation, offering an unparalleled combination of spatial resolution, depth, and precision targeting. By integrating these technologies, the Brainbox TUS solution provides a laboratory-ready system for advanced neuromodulation studies, ensuring a streamlined workflow from planning to execution.
TUS Package
Includes: NeuroFUS PRO, K-Plan, Brainsight Neuronavigation
Efficient Planning and Simulation
K-Plan adds a layer of precision to your ultrasound studies, allowing researchers to simulate ultrasound targeting before delivery. Its advanced computational modelling ensures accurate mapping of stimulation parameters, accounting for anatomical variability and optimising protocol outcomes. Researchers can load K-Plan simulations directly into the Brainsight software for seamless execution, reducing setup time and ensuring alignment with experimental goals.
Integrated Precision
At the heart of the ultrasound package is the NeuroFUS PRO, delivering low-intensity, pulsed ultrasound stimulation to targeted brain regions. With advanced axial steering and multi-channel transducers, the system enables high-resolution targeting at depths ranging from 25mm to 125mm. Its built-in safety and power monitoring features ensure consistent, accurate, and reliable operation across all research applications.
Seamless Neuronavigation
Brainsight Neuronavigation integrates flawlessly with the NeuroFUS PRO, providing real-time visualisation of brain structures and stimulation targets. By combining neuronavigation with the precision of ultrasound stimulation, this solution ensures accurate delivery to even the most complex brain regions. The intuitive interface simplifies targeting, ensuring that researchers can focus on their experiments without compromising accuracy.
Complete Control and Flexibility
Our transcranial ultrasound stimulation solution offers extensive customisation and control, supporting a wide range of experimental designs and research protocols:
- Advanced GUI Integration: Unified control of stimulation, planning, and navigation systems.
- Protocol Database: Access to over 100 pre-loaded protocols, easily customisable for specific research needs.
- Real-Time Monitoring: Visualise power output and transducer performance in real time, ensuring optimal delivery.
- Triggering and Synchronisation: Compatible with external systems, enabling precise timing with neuroimaging or other neuromodulation techniques.
Robust Safety Features
The TUS Package prioritises safety with automated power monitoring, calibration tools, and system safeguards. With tools like the NeuroFUS Tracer and Transducer Performance Test, researchers can monitor and maintain the system's accuracy over time, ensuring reproducible results in every experiment.
Multi-Modality Compatibility
Designed for versatility, the TUS Package integrates with MRI, TMS, EEG, and NIRS modalities, enabling a holistic approach to neuromodulation research. This multi-modality compatibility allows researchers to combine stimulation with neuroimaging for deeper insights into brain function and behaviour.
Applications
This solution is ideal for research applications requiring precise, non-invasive neuromodulation, including:
- Functional brain mapping
- Investigating neural connectivity
- Studying cognitive and behavioural interventions
- Developing therapeutic protocols for neurological disorders
The TUS Package is a cutting-edge, all-in-one solution for researchers seeking advanced tools for transcranial ultrasound stimulation. By combining the NeuroFUS PRO, K-Plan, and Brainsight Neuronavigation, this package offers unmatched precision, flexibility, and integration to support groundbreaking discoveries in neuroscience.
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Pre-Stimulation Planning with K-Plan
Simulate ultrasound delivery with anatomical precision using K-Plan’s advanced modelling, reducing setup time and enhancing targeting accuracy.
Precision-Guided Ultrasound Stimulation
NeuroFUS PRO enables low-intensity, pulsed ultrasound with axial steering and multi-channel transducers for precise, targeted stimulation at depths of 25–125 mm.
Multi-Modality Compatibility
Designed to work alongside TMS, EEG, NIRS, and MRI for multimodal studies exploring neuromodulation, connectivity, and brain function.
Safety-Centric Design
Built-in power monitoring, calibration tools, and system safeguards (including NeuroFUS Tracer and Transducer Performance Test) support consistent and reproducible stimulation.
| Specifications | |
|---|---|
| Targeting Depth | 25mm - 125mm |
| Axial Steering | Advanced control for precise brain region targeting. |
| Optional System Compatibility | MRI, TMS, EEG, NIRS |
| Software | K-Plan Simulation Software, Brainsight Neuronavigation |
| Protocols | Over 100 pre-loaded, customisable protocols |
| Real-Time Monitoring | Live power output and transducer performance feedback |
| Power Monitoring | Automated calibration and monitoring tools |
| Triggering & Synchronisation | Compatible with external neuroimaging or neuromodulation systems |
- Unilateral online ultrasound stimulation of early visual cortex suppresses responses to contralateral visual stimuli. Dunsford, S., Murphy, K., Darrieutort, E., Fouragnan, E., & Ganis, G. (2026). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 19(2).
- Transcranial Ultrasound Stimulation of Internal Globus Pallidus Region and Motor Cortex in Parkinson’s Disease. Lin, Y.-Y., Raies, N., Grippe, T., Gunraj, C. A., Sarica, C., Saha, U. K., Bhattacharya, A., Darmani, G., & Chen, R. (2026). Movement Disorders, 41(2), 416–425.
- Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation. Darmani, G., Ramezanpour, H., Sarica, C., Annirood, R., Grippe, T., Nankoo, J.-F., Fomenko, A., Santyr, B., Zeng, K., Vetkas, A., Samuel, N., Davidson, B., Fasano, A., Lankarany, M., Kalia, S. K., Pichardo, S., Lozano, A. M., & Chen, R. (2025). Nature Communications, 16(1), 2693.
- Optimization of MR acoustic radiation force imaging (MR-ARFI) for human transcranial focused ultrasound. Mohammadjavadi, M., Ash, R. T., Glover, G. H., & Pauly, K. B. (2025). Magnetic Resonance in Medicine, 94(3), 1060–1071.
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound. Tsuchiyagaito, A., Kuplicki, R., Misaki, M., Edwards, L., Camprodon, J. A., Fitzgerald, K., Khalsa, S. S., Philip, N. S., Paulus, M. P., & Guinjoan, S. M. (2025). Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology.
- Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity. Yaakub, S. N., Eraifej, J., Bault, N., Lojkiewiez, M., Bellec, E., Roberts, J., Philip, N. S., Divanbeighi Zand, A. P., Green, A. L., Rushworth, M. F. S., & Fouragnan, E. F. (2025). Nature Communications, 16(1), 10192.
- A frontopolar-temporal circuit determines the impact of social information in macaque decision making. Mahmoodi, A., Harbison, C., Bongioanni, A., Emberton, A., Roumazeilles, L., Sallet, J., Khalighinejad, N., & Rushworth, M. F. S. (2024). Neuron, 112(1), 84-92.e6.
- Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans. Yaakub, S. N., White, T. A., Roberts, J., Martin, E., Verhagen, L., Stagg, C. J., Hall, S., & Fouragnan, E. F. (2023). Nature Communications, 14(1), 5318.
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Associated Techniques
To find out more about the techniques that are applicable to this product, follow the links below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops
