Our Transcranial Ultrasound Stimulation (TUS) package combines the precision of the NeuroFUS PRO TUS System with the planning capabilities of K-Plan and seamless neuronavigation of Brainsight. This fully integrated package is designed to elevate research in non-invasive brain stimulation, offering an unparalleled combination of spatial resolution, depth, and precision targeting. By integrating these technologies, the Brainbox TUS solution provides a laboratory-ready system for advanced neuromodulation studies, ensuring a streamlined workflow from planning to execution.
TUS Package
Includes: NeuroFUS PRO, K-Plan, Brainsight Neuronavigation
Efficient Planning and Simulation
K-Plan adds a layer of precision to your ultrasound studies, allowing researchers to simulate ultrasound targeting before delivery. Its advanced computational modelling ensures accurate mapping of stimulation parameters, accounting for anatomical variability and optimising protocol outcomes. Researchers can load K-Plan simulations directly into the Brainsight software for seamless execution, reducing setup time and ensuring alignment with experimental goals.
Integrated Precision
At the heart of the ultrasound package is the NeuroFUS PRO, delivering low-intensity, pulsed ultrasound stimulation to targeted brain regions. With advanced axial steering and multi-channel transducers, the system enables high-resolution targeting at depths ranging from 25mm to 125mm. Its built-in safety and power monitoring features ensure consistent, accurate, and reliable operation across all research applications.
Seamless Neuronavigation
Brainsight Neuronavigation integrates flawlessly with the NeuroFUS PRO, providing real-time visualisation of brain structures and stimulation targets. By combining neuronavigation with the precision of ultrasound stimulation, this solution ensures accurate delivery to even the most complex brain regions. The intuitive interface simplifies targeting, ensuring that researchers can focus on their experiments without compromising accuracy.
Complete Control and Flexibility
Our transcranial ultrasound stimulation solution offers extensive customisation and control, supporting a wide range of experimental designs and research protocols:
- Advanced GUI Integration: Unified control of stimulation, planning, and navigation systems.
- Protocol Database: Access to over 100 pre-loaded protocols, easily customisable for specific research needs.
- Real-Time Monitoring: Visualise power output and transducer performance in real time, ensuring optimal delivery.
- Triggering and Synchronisation: Compatible with external systems, enabling precise timing with neuroimaging or other neuromodulation techniques.
Robust Safety Features
The TUS Package prioritises safety with automated power monitoring, calibration tools, and system safeguards. With tools like the NeuroFUS Tracer and Transducer Performance Test, researchers can monitor and maintain the system's accuracy over time, ensuring reproducible results in every experiment.
Multi-Modality Compatibility
Designed for versatility, the TUS Package integrates with MRI, TMS, EEG, and NIRS modalities, enabling a holistic approach to neuromodulation research. This multi-modality compatibility allows researchers to combine stimulation with neuroimaging for deeper insights into brain function and behaviour.
Applications
This solution is ideal for research applications requiring precise, non-invasive neuromodulation, including:
- Functional brain mapping
- Investigating neural connectivity
- Studying cognitive and behavioural interventions
- Developing therapeutic protocols for neurological disorders
The TUS Package is a cutting-edge, all-in-one solution for researchers seeking advanced tools for transcranial ultrasound stimulation. By combining the NeuroFUS PRO, K-Plan, and Brainsight Neuronavigation, this package offers unmatched precision, flexibility, and integration to support groundbreaking discoveries in neuroscience.
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Pre-Stimulation Planning with K-Plan
Simulate ultrasound delivery with anatomical precision using K-Plan’s advanced modelling, reducing setup time and enhancing targeting accuracy.
Precision-Guided Ultrasound Stimulation
NeuroFUS PRO enables low-intensity, pulsed ultrasound with axial steering and multi-channel transducers for precise, targeted stimulation at depths of 25–125 mm.
Multi-Modality Compatibility
Designed to work alongside TMS, EEG, NIRS, and MRI for multimodal studies exploring neuromodulation, connectivity, and brain function.
Safety-Centric Design
Built-in power monitoring, calibration tools, and system safeguards (including NeuroFUS Tracer and Transducer Performance Test) support consistent and reproducible stimulation.
Specifications | |
---|---|
Targeting Depth | 25mm - 125mm |
Axial Steering | Advanced control for precise brain region targeting. |
Optional System Compatibility | MRI, TMS, EEG, NIRS |
Software | K-Plan Simulation Software, Brainsight Neuronavigation |
Protocols | Over 100 pre-loaded, customisable protocols |
Real-Time Monitoring | Live power output and transducer performance feedback |
Power Monitoring | Automated calibration and monitoring tools |
Triggering & Synchronisation | Compatible with external neuroimaging or neuromodulation systems |
- Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans. Siti N. Yaakub, Tristan A. White, Jamie Roberts, Eleanor Martin, Lennart Verhagen, Charlotte J. Stagg, Stephen Hall & Elsa F. Fouragnan. Nature Communications, 14(1). September 2023
- Ramped V1 transcranial ultrasonic stimulation modulates but does not evoke visual evoked potentials. Tulika Nandi, Ainslie Johnstone, Eleanor Martin, Catharina Zich, Robert Cooper, Sven Bestmann, Til Ole Bergmann, Bradley Treeby, Charlotte J. Stagg. Brain Stimulation, VOLUME 16, ISSUE 2, P553-555. March 2023
- Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Dominik Pizem, Lubomira Novakova, Martin Gajdos & Irena Rektorova. Journal of Neural Transmission. 2022
- Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements. Kevin A. Caulfield, Holly H. Fleischmann, Claire E. Cox, Julia P. Wolf, Mark S. George, Lisa M. McTeague. Brain Stimulation. August 2022
- Optimizing Transcranial Focused Ultrasound Stimulation: An Open-source Tool for Precise Targeting. Cyril Atkinson- Clement and Marcus Kaiser. Neuromodulation Volume 28, Issue 1, P185-P187. January 2025
- k-Dispatch: Enabling Cost-Optimized Biomedical Workflow Offloading. Marta Jaros and Jiri Jaros. HPDC '24: Proceedings of the 33rd International Symposium on High-Performance Parallel and Distributed Computing. August 2024
Compatible Products
This product can be used in combination with some of our other systems. Find out more by selecting one from the list below.
Added Value
In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:
Training
Installation, Product Training, Technique Training, Bespoke Training
Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions
Research Support
Study Design, Piloting, Technical Information, References
Collaboration
Grant Applications, Industrial Projects, Workshops