One of the complications of research in transcranial electric stimulation (tES) is the choice of montage. Many different experiments claim to stimulate the same site(s) even though the position of their electrodes might differ. Moreover, effects of an opposing polarity occur within the suclus and gyrus immediately near a stimulating electrode, which is not always considered (Rahman et al., 2013; Data et al., 2012). Something that is not often considered is how tissue in proximity to the return - or cathode - electrode is affected during tES, in addition to effects presumably mediated by the anode. At the behavioural level the effect of tES are variable to say the least so it is critical that the consequences tES on brain tissue are fully understood (Bestmann et al., 2015).
Current flow models can confirm whether a tES montage is stimulating brain tissue that it is expected to be stimulated, and to compare montages prior to running an experiment. Current flow modelling involves segmenting a magnetic resonance image of a tES participant into different tissue types - usually skin, scalp, cerebrospinal fluid, grey matter and white matter. Electrodes can then be placed on the scalp of this segmented image to simulate the effect of a tES montage. Electric field is then estimated in each of these tissue types based on their conductivity, shape and proximity to the anode(s) and cathode(s). Peaks in electric field can then be spotted using knowledge of anatomy to identify the sites that are most affected by a tES montage. A particularly useful physiological parameter is the normal component of electric field, which is the electric field perpendicular to the cortex, which changes in orientation from sulcus to gyrus. Such an approach has recently been validated used implanted electrodes in patients, which confirmed that the voltage predicted by current flow models closely corresponds to the actual voltage measurements during tDCS (Huang et al., 2017).
Current flow models have successfully been used to ensure that DLPFC is being stimulated during tDCS (e.g. Bonaiuto et al., 2016). Current flow models have also been used to call into question whether certain tES montages are stimulated a brain region in a way that is assumed. For example, Karabanov et al. (2019) used a current flow model to identify whether an F3-F4 (10-20 EEG co-ordinates) montage stimulates DLPFC, with an effect assumed to proximal beneath the anode. However, the use of current flow models revealed a stimulation pattern that is more complex, with large changes in electric field occurring in between hemispheres in addition to large changes beneath the anode and cathode (Karabanov et al., 2019). In particular, the use of current flow models have revealed that changes in electric field tend to be greatest in between electrodes as opposed to immediately beneath them, where the magnitude of the effect is determined by the shape of the brain tissue. In some cases, this leads to complicated stimulation effect, in other cases this can be used to ensure that current flows in a consistent direction across a gyrus, which has successfully reduced variability in an M1 montage (Rawji et al., 2019).
- Can Transcranial Electrical Stimulation Localize Brain Function?. Anke Ninija Karabanov, Guilherme Bicalho Saturnino, Axel Thielscher, and Hartwig Roman Siebner. Frontiers in Psychology. February 2019
- Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation. Yu Huang, Anli A Liu, Belen Lafon, Daniel Friedman, Michael Dayan, Xiuyuan Wang, Marom Bikson, Werner K Doyle, Orrin Devinsky. ELife. February 2017
- Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models. James J Bonaiuto, Archy de Berker, Sven Bestmann. ELife. December 2016
- Understanding the behavioural consequences of noninvasive brain stimulation. Sven Bestmann, Archy O. de Berker, JamesBonaiuto. Trends in Cognitive Sciences. January 2015
- Cellular effects of acute direct current stimulation: somatic and synaptic terminal effects. Asif Rahman, Davide Reato, Mattia Arlotti, Fernando Gasca, Abhishek Datta, Lucas C Parra, Marom Bikson. The Journal of Physiology. May 2013
- Gyri-precise head model of transcranial direct current stimulation: improved spatial focality using a ring electrode versus conventional rectangular pad. Abhishek Datta, Varun Bansal, Julian Diaz, Jinal Patel, Davide Reato, Marom Bikson. Brain Stimulation. October 2009
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