neuroConn DC-Stimulator PLUS

The neuroConn DC-Stimulator PLUS is a versatile transcranial electrical stimulator (tES) for non-invasive brain stimulation that offers precise, flexible control for all of your tDCS, tACS, and tRNS protocols.

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neuroConn DC-Stimulator PLUS

neuroConn DC-Stimulator PLUS

The neuroConn DC-Stimulator PLUS is one of the most well-established tES devices available, used in an extensive list of publications. In addition to standard features such as microprocessor-controlled constant current source, it also includes a range of advanced optional features such as double-blind sham control, analogue signal control, real-time signal output, and MRI compatibility. The range of options available makes the device highly configurable and suitable for a diverse array of applications.

The stimulator meets the highest safety standards thanks to multistage monitoring of the current path using both hardware and software. By means of continuously monitoring electrode impedance, the stimulator is able to accurately maintain the user-defined current amplitude while also automatically detecting if there is insufficient contact with the skin. It will automatically terminate stimulation to ensure subject safety.

The DC-Stimulator PLUS is not a medical device according to MDD93/42 EEC. The device is intended strictly for neuroscientific research.

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STUDY MODE FOR SHAM STIMULATION

For double-blind sham stimulation control, remember to add the Study Mode option to your system. This option allows the user to select a pre-defined stimulation protocol and depending on the 5-digit code entered by the operator, the current delivered will either follow the active stimulation waveform shape, or a pseudo stimulation output. In both cases, the stimulator display will show the same information during real and sham stimulation.

MRI-COMPATIBLE OPTION

An MRI-compatible upgrade is available for this system, which can be included at the time of purchase, or retrospectively added to your DC-Stimulator PLUS. The 'DC-Stimulator MR' is the most extensively used device for combined tES-MRI studies, due to its reliability in delivering artefact free stimulation during fMRI. It is suitable for use with 1.5T and 3T MRI scanners.

EEG COMPATIBILITY

With the addition of one of three 'Signal Output' options, the DC-Stimulator PLUS offers is well suited to integration with EEG. This features allows the stimulation waveform (amplitude, frequency, shape etc.) to be streamed directly to an EEG system, or other recording devices, in the form of an analogue signal. The recorded stimulation signal can then be used for online or offline artefact correction of the EEG data. The 'Signal Output' option can also be useful in applications where the stimulator output needs to be monitored by an external device; for example, to synchronise the onset of visual or other stimuli.

EXTERNAL STIMULATION CONTROL

Remote, online modulation of stimulation parameters is available with the addition of an analogue input 'Remote Option'. This is particularly useful for research applications where time-locked, synchronised and/or varying stimulation parameters are required; for example tES-EEG applications and dual-site tACS applications.

Number of Channels

1 pair (1 anode, 1 cathode)

Power Supply

Built-in, rechargeable battery

Operating Time

Approximately 6 hours

Stimulation Modes

tDCS, tACS, tRNS, Pulsed tDCS, Sinus (W), Sinus (HW), Analogue Input (optional)

Maximum Voltage

20V

Dimensions

135mm x 225mm x 55mm

Weight

0.8kg

 

 

tDCS Parameters

 

Stimulation Current

max. ±4.5mA (increment 25µA)

Stimulation Duration

15-1800s (increment 15s)

Fade In/Out

0-60s (increment 1s)

 

 

tACS Parameters

 

Stimulation Current (peak-to-peak)

max. 3mA (increment 25µA)

Offset

±1mA (increment 10µA)

Frequency

0.25-250Hz (increment 0.01Hz)

Number of Cycles

1-350000 (increment 1)

Fade In/Out Cycles

0-4500 (increment 1)

Maximum Duration

8 hours
  1. Modulation of network centrality and gray matter microstructure using multi-session brain stimulation and memory training. Friederike Thams, Nadine Külzow, Agnes Flöel, Daria Antonenko.. Human Brain Mapping. April 2022
  2. Combining transcranial direct current stimulation and peripheral electrical stimulation to improve upper limb function in a patient with acute central cord syndrome: a case report. Hideaki Matsuo, Masafumi Kubota, Yasue Hori, Yuya Izubuchi, Ai Takahashi, Shuji Watanabe, Hideaki Nakajima, Akihiko Matsumine. Journal of International Medical Research.. March 2022
  3. Cerebellar noninvasive neuromodulation influences the reactivity of the contralateral primary motor cortex and surrounding areas: a TMS-EMG-EEG study. Lorenzo Rocchi, Danny A. Spampinato, V. Pezzopane, Michael Orth, Patrizia S. Bisiacchi, John C Rothwell & Elias P. Casula. The Cerebellum. March 2022
  4. Exploring the Effects of Brain Stimulation on Musical Taste: tDCS on the Left Dorso-Lateral Prefrontal Cortex—A Null Result. Gemma Massetti, Carlotta Lega, Zaira Cattaneo, Alberto Gallace and Giuseppe Vallar. Brain Sciences. March 2022
  5. Effects of Transcranial Direct Current Stimulation of Bilateral Supplementary Motor Area on the Lower Limb Motor Function in a Stroke Patient with Severe Motor Paralysis: A Case Study. Sora Ohnishi, Naomichi Mizuta, Naruhito Hasui, Junji Taguchi, Tomoki Nakatani and Shu Morioka.. Brain Sciences. March 2022
  6. Single session gamma transcranial alternating stimulation does not modulate working memory in depressed patients and healthy controls. Ulrich Palm, Carolin Baumgartner, Lina Hoffmann, Frank Padberg, Alkomiet Hasanac, Wolfgang Strube, Irina Papazova.. Neurophysiologie Clinique. March 2022
  7. Transcranial Pulsed-Current Stimulation versus Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Pilot, Sham-Controlled Cross-Over Double-Blind Study.. Alice Barra, Martin Rosenfelder, Sepehr Mortaheb, Manon Carrière, Geraldine Martens, Yelena G. Bodien, Leon Morales-Quezada, Andreas Bender, Steven Laureys, Aurore Thibaut, and Felipe Fregni.. Brain Sciences. March 2022
  8. Does transcranial direct current stimulation enhance cognitive performance in Parkinson’s disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study. Serkan Aksu, Atilla Uslu, Pınar İşçen, Emine Elif Tülay, Huzeyfe Barham, Ahmet Zihni Soyata, Asli Demirtas-Tatlidede, Gülsen Babacan Yıldız, Başar Bilgiç, Haşmet Hanağası, Adam J. Woods, Sacit Karamürsel & Fatma Aytül Uyar.. Neurological Sciences. March 2022
  9. Comparing different montages of transcranial direct current stimulation on dual-task walking and cortical activity in chronic stroke: double-blinded randomized controlled trial. Pei-Ling Wong, Yea-Ru Yang, Shun-Chang Tang, Shi-Fong Huang & Ray-Yau Wang. BMC Neurology. March 2022
  10. Towards precise brain stimulation: Is electric field simulation related to neuromodulation?. Daria Antonenko, Axel Thielscher, Guilherme Bicalho Saturnino, Semiha Aydine BerndIttermann, Ulrike Grittner, & Agnes Flöel. Brain Stimulation. October 2019
  11. Slow oscillatory transcranial direct current stimulation (so-tDCS) during slow wave sleep has no effects on declarative memory in healthy young subjects. A. Bueno-Lopez, T. Eggert, H. Dorn, & H. Danker-Hopfe. Brain Stimulation. August 2019
  12. Beta Power May Mediate the Effect of Gamma-TACS on Motor Performance. Atalanti A. Mastakouri, Bernhard Scholkopf, and Moritz Grosse-Wentrup. arXiv. May 2019
  13. Intrinsic 40Hz-phase asymmetries predict tACS effects during conscious auditory perception. Jan Meier, Guido Nolte, Till R. Schneider, Andreas K. Engel, Gregor Leicht, & Christoph Mulert. PLOS ONE. April 2019
  14. Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study. OliviaDennison, JieGao, Lee Wei Lim, Charlotte J.Stagg, and LucaAquili. Brain Stimulation. March 2019
  15. Effects of transcranial alternating-current stimulation to secondary motor areas on cortical oscillations in stroke patients. Lutz A. Krawinkel, Marlene Bönstrup, Jan F. Feldheim, Robert Schulz, Winifried Backhaus, Till R. Schneider, Jonas Misselhorn, Bastian Cheng, & Christian Gerloff. bioRxiv. March 2019
  16. Low-frequency alternating current stimulation rhythmically suppresses gamma-band oscillations and impairs perceptual performance. Jim D.Herring, Sophie Esterer, Tom R. Marshall, Ole Jensen, & Til O.Bergmann. NeuroImage. January 2019
  17. Lack of effect of transcranial direct current stimulation (tDCS) on short-term smoking cessation: Results of a randomized, sham-controlled clinical trial. Mary Falcone, Leah Bernardo, E. Paul Wileyto, Cheyenne Allenby, Anne Marie Burke, Roy Hamilton, Mario Cristancho, Rebecca L. Ashare, James Loughead, & CarynLerman. Drug and Alcohol Dependence. January 2019
  18. Prefrontal brain stimulation during food-related inhibition training: effects on food craving, food consumption and inhibitory control. Jemma Sedgmond, Natalia S. Lawrence, Frederick Verbruggen, Sinead Morrison, Christopher D. Chambers and Rachel C. Adams. Royal Society Open Science. January 2019
  19. Can electric fields explain inter-individual variability in transcranial direct current stimulation of the motor cortex?. Ilkka Laakso, Marko Mikkonen, Soichiro Koyama, Akimasa Hirata & Satoshi Tanaka. Scientific Reports. 2019
  20. Removal of Gross Artifacts of Transcranial Alternating Current Stimulation in Simultaneous EEG Monitoring. Siddharth Kohli and Alexander J. Casson. Sensors. September 2018
  21. 1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla. Kayla Ryan, Krzysztof Wawrzyn, Joseph S. Gati, Blaine A. Chronik, Dickson Wong, Neil Duggal, & Robert Bartha. PLOS ONE. August 2018
  22. Closed-Loop Slow-Wave tACS Improves Sleep-Dependent Long-Term Memory Generalization by Modulating Endogenous Oscillations. Nicholas Ketz, Aaron P. Jones, Natalie B. Bryant, Vincent P. Clark and Praveen K. Pilly. The Journal of Neuroscience. August 2018
  23. Absence of Alpha-tACS Aftereffects in Darkness Reveals Importance of Taking Derivations of Stimulation Frequency and Individual Alpha Variability Into Account. Heiko I. Stecher and Christoph S. Herrmann. Frontiers in Psychology. June 2018
  24. Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task. Matt Craddock, Ekaterini Klepousniotou, Wael el-Deredy, Ellen Poliakoff, & Donna Lloyd. bioRxiv. May 2018
  25. The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults. Shane Fresnoza, Monica Christova, Theresa Feil, Eugen Gallasch, Christof Körner, Ulrike Zimmer & Anja Ischebeck. Experimental Brain Research. 2018
  26. Multi-frequency tACS has lasting effects on neural synchrony and audiovisual responses. Tobias Bockhorsta, Joachim Ahlbecka, Florian Piepera, Gerhard Englera, and Andreas K. Engel. bioRxiv. 2018
  27. Individual electric field predicts functional connectivity changes after anodal transcranial direct-current stimulation in chronic stroke. Yuan, K. et al.. Neuroscience Research, 186, pp. 21–32. 2023

NeuroConn DC Stimulator Plus Brochure

Associated Techniques

To find out more about the techniques that are applicable to this product, follow the links below.

Added Value

In addition to supplying and supporting a wide range of neuroscience products, Brainbox offers additional value in a number of areas that can benefit our customers, including:

Training
Installation, Product Training, Technique Training, Bespoke Training

Lab Support
System Upgrades, Testing, Calibration, System Integration, Bespoke Solutions

Research Support
Study Design, Piloting, Technical Information, References

Collaboration
Grant Applications, Industrial Projects, Workshops

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